Evaluation of Factors Associated with Adult Sepsis Prognosis

Aim: The aim of this study was to evaluate the factors affecting the prognosis of sepsis in patients admitted to the intensive care unit (ICU). Materials and Methods: We retrospectively included all adult patients admitted to the ICU, who were diagnosed with sepsis according to the Sepsis 3 criteria between September 2013 and February 2021. Demographic, clinical data and laboratory results were recorded. Results: Of the 245 patients in the ICU, 100 (40.8%) died during the 30-day follow-up. In univariate logistic regression analysis, Sequential Organ Failure Assessment (SOFA) score, vasopressor need, immunosuppressive treatment, neutropenic fever, hematological malignancy, pneumonia, urinary tract infection, lactate, ferritin, lactate dehydrogenase (LDH), and albumin levels were found to be independently associated with mortality. When evaluated in terms of prognostic significance in ROC curve, the optimal cutoff values for 30-day mortality were 7 for SOFA score (AUC=0.713, p<0.001), 1518 <mu>g/L for ferritin (AUC=0.732, p<0.001), 324 U/L for LDH (AUC=0.593, p=0.035), and 2.9 g/dL for albumin (AUC=0.632, p=0.001), in mortality. Using these values, in multivariate logistic regression analysis, we determined that a SOFA score >7 [odds ratio (OR): 95% confidence interval (CI): 9.66 (1.16-80.82), p=0.036], history of immunosuppressive treatment [OR 95% CI: 12.41 (1.45-106.17), p=0.021], and ferritin levels >1518 mu g/L [OR 95% CI: 9.46 (1.36-65.79), p=0.023] were independent risk factors for 30-day mortality. Conclusion: In our single-center study, serum ferritin level was determined to be a valuable prognostic biomarker in patients with sepsis.