Emerging roles of TBK1 in cancer immunobiology

被引：5
作者：
Miranda, Alex [1 ,2 ]
Shirley, Carl A. [1 ]
Jenkins, Russell W. [1 ,2 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Mass Gen Canc Ctr, Krantz Family Ctr Canc Res,Dept Med, Boston, MA 02114 USA
[2] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
来源：
TRENDS IN CANCER | 2024年 / 10卷 / 06期
关键词：
IKK-EPSILON; ACTIVATION; RESISTANCE; CELLS; TANK; IMMUNOTHERAPY; PATHWAY; DRIVEN; INFLAMMATION; HOMEOSTASIS;
D O I：
10.1016/j.trecan.2024.02.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation. While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene by virtue of its role in modulating cellular responses to inflammatory signals emanating from the immune system. Beyond its effect on cancer cells, TBK1 appears to regulate lymphoid and myeloid cells in the tumor immune microenvironment. In this review, we detail recent advances in our understanding of the tumor-intrinsic and -extrinsic roles and regulation of TBK1 in tumor immunity.
引用
收藏
页码：531 / 540
页数：10
相关论文
共 77 条
  • [1] EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
    Ardito, Christine M.
    Gruener, Barbara M.
    Takeuchi, Kenneth K.
    Lubeseder-Martellato, Clara
    Teichmann, Nicole
    Mazur, Pawel K.
    DelGiorno, Kathleen E.
    Carpenter, Eileen S.
    Halbrook, Christopher J.
    Hall, Jason C.
    Pal, Debjani
    Briel, Thomas
    Herner, Alexander
    Trajkovic-Arsic, Marija
    Sipos, Bence
    Liou, Geou-Yarh
    Storz, Peter
    Murray, Nicole R.
    Threadgill, David W.
    Sibilia, Maria
    Washington, M. Kay
    Wilson, Carole L.
    Schmid, Roland M.
    Raines, Elaine W.
    Crawford, Howard C.
    Siveke, Jens T.
    [J]. CANCER CELL, 2012, 22 (03) : 304 - 317
  • [2] TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability
    Bakouny, Ziad
    Barbie, David A.
    [J]. CANCER DISCOVERY, 2020, 10 (03) : 348 - 350
  • [3] Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    Barbie, David A.
    Tamayo, Pablo
    Boehm, Jesse S.
    Kim, So Young
    Moody, Susan E.
    Dunn, Ian F.
    Schinzel, Anna C.
    Sandy, Peter
    Meylan, Etienne
    Scholl, Claudia
    Froehling, Stefan
    Chan, Edmond M.
    Sos, Martin L.
    Michel, Kathrin
    Mermel, Craig
    Silver, Serena J.
    Weir, Barbara A.
    Reiling, Jan H.
    Sheng, Qing
    Gupta, Piyush B.
    Wadlow, Raymond C.
    Le, Hanh
    Hoersch, Sebastian
    Wittner, Ben S.
    Ramaswamy, Sridhar
    Livingston, David M.
    Sabatini, David M.
    Meyerson, Matthew
    Thomas, Roman K.
    Lander, Eric S.
    Mesirov, Jill P.
    Root, David E.
    Gilliland, D. Gary
    Jacks, Tyler
    Hahn, William C.
    [J]. NATURE, 2009, 462 (7269) : 108 - U122
  • [4] Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription
    Bonnard, M
    Mirtsos, C
    Suzuki, S
    Graham, K
    Huang, JN
    Ng, M
    Itié, A
    Wakeham, A
    Shahinian, A
    Henzel, WJ
    Elia, AJ
    Shillinglaw, W
    Mak, TW
    Cao, ZD
    Yeh, WC
    [J]. EMBO JOURNAL, 2000, 19 (18) : 4976 - 4985
  • [5] RaIB GTPase-mediated activation of the IκB family kinase TBK1 couples innate immune signaling to tumor cell survival
    Chien, Yuchen
    Kim, Sungchan
    Bumeister, Ron
    Loo, Yueh-Ming
    Kwon, Sung Won
    Johnson, Cynthia L.
    Balakireva, Mirey G.
    Romeo, Yves
    Kopelovich, Levy
    Gale, Michael, Jr.
    Yeaman, Charles
    Camonis, Jacques H.
    Zhao, Yingming
    White, Michael A.
    [J]. CELL, 2006, 127 (01) : 157 - 170
  • [6] TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer
    Cooper, Jonathan M.
    Ou, Yi-Hung
    McMillan, Elizabeth A.
    Vaden, Rachel M.
    Zaman, Aubhishek
    Bodemann, Brian O.
    Makkar, Gurbani
    Posner, Bruce A.
    White, Michael A.
    [J]. CANCER RESEARCH, 2017, 77 (18) : 5077 - 5094
  • [7] Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma
    Eskiocak, Banu
    McMillan, Elizabeth A.
    Mendiratta, Saurabh
    Kollipara, Rahul K.
    Zhang, Hailei
    Humphries, Caroline G.
    Wang, Changguang
    Garcia-Rodriguez, Jose
    Ding, Ming
    Zaman, Aubhishek
    Rosales, Tracy I.
    Eskiocak, Ugur
    Smith, Michael P.
    Sudderth, Jessica
    Komurov, Kakajan
    Deberardinis, Ralph J.
    Wellbrock, Claudia
    Davies, Michael A.
    Wargo, Jennifer A.
    Yu, Yonghao
    De Brabander, Jef K.
    Williams, Noelle S.
    Chin, Lynda
    Rizos, Helen
    Long, Georgina V.
    Kittler, Ralf
    White, Michael A.
    [J]. CANCER DISCOVERY, 2017, 7 (08) : 832 - 851
  • [8] MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
    Fang, Run
    Jiang, Qifei
    Zhou, Xiang
    Wang, Chenguang
    Guan, Yukun
    Tao, Jianli
    Xi, Jianzhong
    Feng, Ji-Ming
    Jiang, Zhengfan
    [J]. PLOS PATHOGENS, 2017, 13 (11)
  • [9] TBK1 and IKKe act like an OFF switch to limit NLRP3 inflammasome pathway activation
    Fischer, Fabian A.
    Mies, Linda F. M.
    Nizami, Sohaib
    Pantazi, Eirini
    Danielli, Sara
    Demarco, Benjamin
    Ohlmeyer, Michael
    Lee, Michelle Sue Jann
    Coban, Cevayir
    Kagan, Jonathan C.
    Di Daniel, Elena
    Bezbradica, Jelena S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (38)
  • [10] IKKε and TBK1 are essential components of the IRF3 signaling pathway
    Fitzgerald, KA
    McWhirter, SM
    Faia, KL
    Rowe, DC
    Latz, E
    Golenbock, DT
    Coyle, AJ
    Liao, SM
    Maniatis, T
    [J]. NATURE IMMUNOLOGY, 2003, 4 (05) : 491 - 496
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