The impact of COVID-19 on "biological aging"

被引：3
作者：
Amanullah, Fathima Humaira [1 ]
Alam, Tanvir [2 ]
El Hajj, Nady [1 ,2 ]
Bejaoui, Yosra [1 ]
机构：
[1] Hamad Bin Khalifa Univ, Qatar Fdn, Coll Hlth & Life Sci, Doha, Qatar
[2] Hamad Bin Khalifa Univ, Qatar Fdn, Coll Sci & Engn, Doha, Qatar
来源：
FRONTIERS IN IMMUNOLOGY | 2024年 / 15卷
关键词：
biological aging; epigenetic clocks; COVID-19; telomere attrition; DNA methylation; DNA; RISK; AGE;
D O I：
10.3389/fimmu.2024.1399676
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The global impact of the SARS-CoV-2 pandemic has been unprecedented, posing a significant public health challenge. Chronological age has been identified as a key determinant for severe outcomes associated with SARS-CoV-2 infection. Epigenetic age acceleration has previously been observed in various diseases including human immunodeficiency virus (HIV), Cytomegalovirus (CMV), cardiovascular diseases, and cancer. However, a comprehensive review of this topic is still missing in the field. In this review, we explore and summarize the research work focusing on biological aging markers, i.e., epigenetic age and telomere attrition in COVID-19 patients. From the reviewed articles, we identified a consistent pattern of epigenetic age dysregulation and shortened telomere length, revealing the impact of COVID-19 on epigenetic aging and telomere attrition.
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页数：7
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