Mn-Catalyzed Ligand-Free One-Pot Synthesis of (E)-6,7-Dihydrodibenzo[b,j][1,7]phenanthrolines and (E)-1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridines through Dehydrogenative Friedlander Annulation/C(sp3)-H Functionalization

被引：6

作者：

Nagarajan, Sambavi ^{[1
]}

Fazlur-Rahman, Nawaz Khan ^{[1
]}

机构：

[1] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India

来源：

ACS OMEGA | 2024年 / 9卷 / 23期

关键词：

DEEP EUTECTIC SOLVENTS; CHOLINE CHLORIDE; QUINOLINE; DNA; DERIVATIVES; ANTICANCER; EFFICIENT; ACIDS; ANTIBACTERIAL; ALCOHOLS;

D O I：

10.1021/acsomega.4c00188

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient, MnO2-catalyzed ligand-free synthesis of (E)-6,7-dihydrodibenzo[b,j][1,7]phenanthrolines, 13, and (E)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines, 15, utilizing, 2-amino-5-chloro-benzhydrol, 9, acridinol, 10, or 1-benzyl-4-piperidinol, 14, and benzyl alcohols, 11, is reported. The MnO2-catalyzed dehydrogenative Friedlander annulation utilizing ChCl/p-TSA (DES-1) and subsequent C(sp(3))-H functionalization with TBAB/p-TSA (DES-2) was effected at 100 degrees C. The optimized reaction conditions gave excellent product yields, and the products were evaluated for their by UV absorption and fluorescence emission studies.

引用

页码：24464 / 24476

页数：13

共 8 条

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