Programmed death receptor-1 and programmed death ligand-1 checkpoint inhibition-associated bullous pemphigoid: a propensity-matched retrospective cohort study

被引：2

作者：

Sarkovics, Katelyn ^{[1
]}

Kolodney, Joanna A. ^{[2
]}

Kolodney, Michael S. ^{[1
]}

机构：

[1] West Virginia Univ, Dept Dermatol, Morgantown, WV 26506 USA

[2] West Virginia Univ, Dept Med, Div Hematol Oncol, Morgantown, WV USA

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2024年 / 191卷 / 02期

关键词：

D O I：

10.1093/bjd/ljae172

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We provide a comparison of the bullous pemphigoid (BP)-free survival probability in patients starting PD-1/PD-L1 inhibitors and DPP-4 inhibitors that has not been previously demonstrated in other studies. A propensity-matched retrospective cohort study performed with TriNetX participants revealed a significantly increased risk of BP in patients starting PD-1/PD-L1 inhibitors, especially in male patients and those aged > 65years.

引用

页码：299 / 300

页数：2

共 5 条

[1] A retrospective case series of 20 patients with immunotherapy- induced bullous pemphigoid with emphasis on management outcomes [J].

Bur, Delfina ;

Patel, Anisha B. ;

Nelson, Kelly ;

Huen, Auris ;

Pacha, Omar ;

Phillips, Rhea ;

Heberton, Meghan .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2022, 87 (06) :1394-1395

[2] Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance [J].

Martins, Filipe ;

Sofiya, Latifyan ;

Sykiotis, Gerasimos P. ;

Lamine, Faiza ;

Maillard, Michel ;

Fraga, Montserrat ;

Shabafrouz, Keyvan ;

Ribi, Camillo ;

Cairoli, Anne ;

Guex-Crosier, Yan ;

Kuntzer, Thierry ;

Michielin, Olivier ;

Peters, Solange ;

Coukos, Georges ;

Spertini, Francois ;

Thompson, John A. ;

Obeid, Michel .

NATURE REVIEWS CLINICAL ONCOLOGY, 2019, 16 (09) :563-580

[3] Autoimmune bullous dermatoses in cancer patients treated by immunotherapy: a literature review and Italian multicentric experience [J].

Merli, Martina ;

Accorinti, Martina ;

Romagnuolo, Maurizio ;

Marzano, Angelo ;

Di Zenzo, Giovanni ;

Moro, Francesco ;

Antiga, Emiliano ;

Maglie, Roberto ;

Cozzani, Emanuele ;

Parodi, Aurora ;

Gasparini, Giulia ;

Sollena, Pietro ;

De Simone, Clara ;

Caproni, Marzia ;

Pisano, Luigi ;

Fattore, Davide ;

Balestri, Riccardo ;

Sena, Paolo ;

Vezzoli, Pamela ;

Teoli, Miriam ;

Ardigo, Marco ;

Vassallo, Camilla ;

Michelerio, Andrea ;

Satta, Rosanna Rita ;

Dika, Emi ;

Melotti, Barbara ;

Ribero, Simone ;

Quaglino, Pietro .

FRONTIERS IN MEDICINE, 2023, 10

[4]

Murrell DF., 2020, Acta Derm Venereol, V100, padv00224

[5] Bullous disorders associated with anti-PD-1 and anti-PD-L1 therapy: A retrospective analysis evaluating the clinical and histopathologic features, frequency, and impact on cancer therapy [J].

Siegel, Jacob ;

Totonchy, Mariam ;

Damsky, William ;

Berk-Krauss, Juliana ;

Castiglione, Frank, Jr. ;

Sznol, Mario ;

Petrylak, Daniel P. ;

Fischbach, Neal ;

Goldberg, Sarah B. ;

Decker, Roy H. ;

Stamatouli, Angeliki M. ;

Hafez, Navid ;

Glusac, Earl J. ;

Tomayko, Mary M. ;

Leventhal, Jonathan S. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018, 79 (06) :1081-1088

← 1 →