An imidazo[1,2-a]pyridine-functionalized xanthene fluorescent probe for naked-eye detection of Hg2+ and its application in cell imaging and test strips

被引：3

作者：

Han, Xu-Hong ^{[1
]}

Zhao, Piao ^{[1
]}

Tang, Meng-Ke ^{[2
]}

Yang, Lei ^{[2
]}

Wang, Qing ^{[2
]}

Zhang, Shu-Sheng ^{[2
]}

机构：

[1] Linyi Univ, Coll Chem & Chem Engn, Linyi 276005, Peoples R China

[2] Linyi Univ, Sch Med, Shandong Prov Key Lab Detect Technol Tumor Markers, Linyi 276005, Peoples R China

来源：

SENSORS & DIAGNOSTICS | 2024年 / 3卷 / 06期

基金：

中国国家自然科学基金;

关键词：

SPIROLACTAM RING; FOOD-CHAIN; ZN2+ IONS; CHEMOSENSOR; MERCURY; RISK; DYE;

D O I：

10.1039/d4sd00090k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An imidazo[1,2-a]pyridine-functionalized xanthene dye (Rh-Ip) was designed and developed as a fluorescent probe (Rh-Ip-Hy) for Hg2+ by introducing spirolactam to the molecule. The probe Rh-Ip-Hy with a ring-closed spirolactam structure reacts with Hg2+ to form a fluorescent ring-opened spirolactone structure. Due to its asymmetric structure and the presence of a Lewis base site, the probe exhibits a larger Stokes shift and higher pH tolerance than the traditional xanthene dyes and probes. Furthermore, the probe is highly selective to Hg2+ within a wide pH range of 5.0-11.0. The probe Rh-Ip-Hy also exhibits low cytotoxicity and can be used for the detection of Hg2+ in living HeLa cells through fluorescence imaging. Finally, a paper-based test strip was prepared and successfully applied for the detection of Hg2+ in tap water and lake water samples.

引用

页码：1062 / 1067

页数：6

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