IL-6 pathway in the liver: From physiopathology to therapy

被引：717

作者：

Schmidt-Arras, Dirk ^{[1
]}

Rose-John, Stefan ^{[1
]}

机构：

[1] Univ Kiel, Inst Biochem, Olshausenstr 40, D-24098 Kiel, Germany

来源：

JOURNAL OF HEPATOLOGY | 2016年 / 64卷 / 06期

关键词：

Interleukin-6; Interleukin-6-receptor; Trans-signaling; Inflammation; Cancer; Liver regeneration; ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY; SOLUBLE INTERLEUKIN-6 RECEPTOR; ACUTE-PHASE RESPONSE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; SKELETAL-MUSCLE; PROGENITOR CELLS; IN-VIVO; HEPATIC INFLAMMATION; MONOCLONAL-ANTIBODY;

D O I：

10.1016/j.jhep.2016.02.004

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple functions in the body. In the liver, IL-6 is an important inducer of the acute phase response and infection defense. IL-6 is furthermore crucial for hepatocyte homeostasis and is a potent hepatocyte mitogen. It is not only implicated in liver regeneration, but also in metabolic function of the liver. However, persistent activation of the IL-6 signaling pathway is detrimental to the liver and might ultimately result in the development of liver tumors. On target cells IL-6 can bind to the signal transducing subunit gp130 either in complex with the membrane-bound or with the soluble IL-6 receptor to induce intracellular signaling. In this review we describe how these different pathways are involved in the physiology and pathophyiology of the liver. We furthermore discuss how IL-6 pathways can be selectively inhibited and therapeutically exploited for the treatment of liver pathologies. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：1403 / 1415

页数：13

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