Preoperative chemoradiotherapy but not chemotherapy is associated with reduced risk of postoperative pancreatic fistula after pancreatoduodenectomy for pancreatic ductal adenocarcinoma: a nationwide analysis

被引：5

作者：

Wismans, Leonoor, V ^{[1
]}

Suurmeijer, J. Annelie ^{[2
,3
]}

van Dongen, Jelle C. ^{[1
]}

Bonsing, Bert A. ^{[4
]}

Van Santvoort, Hjalmar C. ^{[5
]}

Wilmink, Johanna W. ^{[3
,6
]}

van Tienhoven, Geertjan ^{[3
,7
]}

de Hingh, Ignace H. ^{[8
]}

Lips, Daan J. ^{[9
]}

van der Harst, Erwin ^{[10
]}

de Meijer, Vincent E. ^{[11
]}

Patijn, Gijs A. ^{[12
]}

Bosscha, Koop ^{[13
]}

Stommel, Martijn W. ^{[14
]}

Festen, Sebastiaan ^{[15
]}

den Dulk, Marcel ^{[16
]}

Nuyttens, Joost J. ^{[17
]}

Intven, Martijn P. W. ^{[18
]}

de Vos-Geelen, Judith ^{[19
]}

Molenaar, I. Quintus ^{[5
]}

Busch, Olivier R. ^{[2
,3
]}

Koerkamp, Bas Groot ^{[1
]}

Besselink, Marc G. ^{[2
,3
]}

van Eijck, Casper H. J. ^{[1
]}

机构：

[1] Erasmus Univ, Dept Surg, Med Ctr, Rg 231,Dr Molenwaterpl 40, Rotterdam, Netherlands

[2] Locat Univ Amsterdam, Dept Surg, Amsterdam UMC, Amsterdam, Netherlands

[3] Canc Ctr Amsterdam, Amsterdam, Netherlands

[4] Leiden Univ, Med Ctr, Dept Surg, Leiden, Netherlands

[5] St Antonius Hosp Nieuwegein, Reg Acad Canc Ctr Utrecht, Dept Surg, Nieuwegein, Netherlands

[6] Locat Univ Amsterdam, Dept Med Oncol, Amsterdam UMC, Amsterdam, Netherlands

[7] Locat Univ Amsterdam, Dept Radiat Oncol, Amsterdam UMC, Amsterdam, Netherlands

[8] Catharina Hosp, Dept Surg, Eindhoven, Netherlands

[9] Med Spectrum Twente, Dept Surg, Enschede, Netherlands

[10] Maasstad Hosp, Dept Surg, Rotterdam, Netherlands

[11] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Groningen, Netherlands

[12] Isala Clin, Dept Surg, Zwolle, Netherlands

[13] Jeroen Bosch Ziekenhuis, Dept Surg, Den Bosch, Netherlands

[14] Radboud Univ Nijmegen, Dept Surg, Med Ctr, Nijmegen, Netherlands

[15] OLVG, Dept Surg, Amsterdam, Netherlands

[16] Maastricht Univ, Dept Surg, Med Ctr, Maastricht, Netherlands

[17] Erasmus Univ, Dept Radiat Oncol, Med Ctr, Rotterdam, Netherlands

[18] Univ Med Ctr Utrecht, Dept Radiat Oncol, Utrecht, Netherlands

[19] Maastricht Univ Med Ctr, Dept Med Oncol, Maastricht, Netherlands

来源：

SURGERY | 2024年 / 175卷 / 06期

关键词：

INTERNATIONAL STUDY-GROUP; NEOADJUVANT THERAPY; SURGERY; CHEMORADIATION; DEFINITION; OUTCOMES; IMPACT;

D O I：

10.1016/j.surg.2024.01.029

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Postoperative pancreatic fistula remains the leading cause of significant morbidity after pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Preoperative chemoradiotherapy has been described to reduce the risk of postoperative pancreatic fistula, but randomized trials on neoadjuvant treatment in pancreatic ductal adenocarcinoma focus increasingly on preoperative chemotherapy rather than preoperative chemoradiotherapy. This study aimed to investigate the impact of preoperative chemotherapy and preoperative chemoradiotherapy on postoperative pancreatic fistula and other pancreatic-specific surgery related complications on a nationwide level.

引用

页码：1580 / 1586

页数：7

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