HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus

被引：5
作者：
Lurain, Kathryn A. [1 ]
Ramaswami, Ramya [1 ]
Krug, Laurie T. [1 ]
Whitby, Denise [2 ]
Ziegelbauer, Joseph M. [1 ]
Wang, Hao-Wei [3 ]
Yarchoan, Robert [1 ]
机构：
[1] Ctr Canc Res, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA
[2] Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Viral Oncol Sect, Leidos Biomed Res, Frederick, MD USA
[3] NCI, Lab Pathol, Bethesda, MD USA
来源：
CLINICAL MICROBIOLOGY REVIEWS | 2024年 / 37卷 / 03期
基金：
美国国家卫生研究院;
关键词：
EBV; KSHV; Kaposi; HIV; AIDS; lymphoma; gammaherpesvirus; Castleman; PRIMARY EFFUSION LYMPHOMA; MULTICENTRIC CASTLEMAN DISEASE; PEGYLATED LIPOSOMAL DOXORUBICIN; PROTEIN-COUPLED RECEPTOR; NF-KAPPA-B; ACTIVE ANTIRETROVIRAL THERAPY; POSITRON-EMISSION-TOMOGRAPHY; CLASSICAL HODGKIN LYMPHOMA; FLICE INHIBITORY PROTEIN; NUCLEAR ANTIGEN;
D O I：
10.1128/cmr.00022-23
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin tumor in the USA. It soon became apparent that AIDS was also associated with an increased incidence of high-grade lymphomas caused by Epstein-Barr virus (EBV). The association of AIDS with KS remained a mystery for more than a decade until Kaposi sarcoma-associated herpesvirus (KSHV) was discovered and found to be the cause of KS. KSHV was subsequently found to cause several other diseases associated with AIDS and human immunodeficiency virus (HIV) infection. People living with HIV/AIDS continue to have an increased incidence of certain cancers, and many of these cancers are caused by EBV and/or KSHV. In this review, we discuss the epidemiology, virology, pathogenesis, clinical manifestations, and treatment of cancers caused by EBV and KSHV in persons living with HIV.
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页数：48
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