Lymphedema and Axillary Sentinel Lymph Node Biopsy (SLNB) in Node-Negative Patients with Breast Cancer

Background: Breast cancer (BC) poses a significant health concern for females, often resulting in complications such as lymphedema due to treatment effects. Objectives: This study examines the link between lymphedema and the number of removed negative axillary lymph nodes (LNs) after sentinel lymph node biopsy (SLNB) in BC patients. Methods: A prospective study from 2016 to 2019 included 150 eligible women out of 1 600 BC patients who underwent axillary sentinel node biopsy (SNB). The prognostic value of isolated negative nodes and BMI in predicting lymphedema post-SLNB was analyzed. Results: Among 950 women receiving radiotherapy, 4% developed lymphedema. Notably, patients with lymphedema were younger (average age 53.34 years). BMI didn't differ significantly, but the number of removed sentinel LN-negatives was crucial. Patients with 4 - 5 nodes removed had an 89.47% likelihood, while those with 1- 3 nodes had zero incidence. Conclusions: BC -related lymphedema significantly impacts patient well-being. Our study establishes a direct correlation between the number of removed negative LNs and the severity of edema, emphasizing the need for further research.