Proton Pump Inhibitors Induced Hyponatremia in a Liver Transplanted Patient-The Role of Deprescribing: A Case Report and Literature Review

被引：1

作者：

Marciano, Gianmarco ^{[1
]}

Caroleo, Benedetto ^{[2
]}

Catarisano, Luca ^{[1
]}

Cocchis, Donatella ^{[3
]}

Palleria, Caterina ^{[1
,4
]}

De Sarro, Giovambattista ^{[1
,4
]}

Gallelli, Luca ^{[1
,4
]}

机构：

[1] Renato Dulbecco Univ Hosp, Operat Unit Pharmacol & Pharmacovigilance, I-88100 Catanzaro, Italy

[2] Soverato Hosp, Operat Unit Internal Med, ASP7 Catanzaro, I-88100 Catanzaro, Italy

[3] Citta Salute Hosp, Dept Liver Transplants, I-10126 Turin, Italy

[4] Magna Graecia Univ Catanzaro, Res Ctr FASUMG, Dept Hlth Sci, I-88100 Catanzaro, Italy

来源：

REPORTS | 2024年 / 7卷 / 02期

关键词：

liver transplant; immunosuppressants; deprescribing; adverse drug reaction; hyponatremia; pantoprazole; MILD HYPONATREMIA; RISK;

D O I：

10.3390/reports7020033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Liver transplant patients are frail subjects due to lifelong therapy with immunosuppressants. In these patients, comorbidity and polytherapy increase the risk of adverse drug reactions. In this study, we report the development of hyponatremia, probably related to pantoprazole in a liver transplant patient. Sertraline dismission and treatment with sodium chloride did not improve clinical symptoms and laboratory levels. Pantoprazole dismission induced an improvement in clinical symptoms and the normalization of sodium levels. A five-month follow-up revealed the absence of clinical symptoms and normal serum sodium levels.

引用

页数：7

共 24 条

[1] The Safety of Long-term Daily Usage of a Proton Pump Inhibitor: A Literature Review [J].

Abbas, Mohammed K. ;

Zaidi, Abdul Rehman Z. ;

Robert, Chris A. ;

Thiha, Suyeewin ;

Malik, Bilal Haider .

CUREUS JOURNAL OF MEDICAL SCIENCE, 2019, 11 (09)

[2]

Ahmed A., Proton Pump Inhibitors

[3]

AIFA Agenzia Italiana del Farmaco, 2016, Riassunto Delle Caratterisiche del ProdottoCiqorin

[4]

[Anonymous], Agenzia Italiana del Farmaco

[5] RISK OF PROTON PUMP INHIBITOR-INDUCED MILD HYPONATREMIA IN OLDER ADULTS [J].

Buon, Marie ;

Gaillard, Cathy ;

Martin, Jocelyne ;

Fedrizzi, Sophie ;

Mosquet, Brigitte ;

Coquerel, Antoine ;

Saint Paul, Laure Peyro .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2013, 61 (11) :2052-2054

[6] EASL Clinical Practice Guidelines: Liver transplantation [J].

Burra, Patrizia ;

Burroughs, Andrew ;

Graziadei, Ivo ;

Pirenne, Jacques ;

Valdecasas, Juan Carlos ;

Muiesan, Paolo ;

Samuel, Didier ;

Forns, Xavier ;

Burroughs, Andrew .

JOURNAL OF HEPATOLOGY, 2016, 64 (02) :433-485

[7] International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients [J].

Charlton, Michael ;

Levitsky, Josh ;

Aqel, Bashar ;

O'Grady, John ;

Hemibach, Julie ;

Rinella, Mary ;

Fung, John ;

Ghabril, Marwan ;

Thomason, Ray ;

Burra, Patrizia ;

Little, Ester Coelho ;

Berenguer, Marina ;

Shaked, Abraham ;

Trotter, James ;

Roberts, John ;

Rodriguez-Davalos, Manuel ;

Rela, Mohamed ;

Pomfret, Elizabeth ;

Heyrend, Caroline ;

Gallegos-Orozco, Juan ;

Saliba, Faouzi .

TRANSPLANTATION, 2018, 102 (05) :727-743

[8] Immunosuppression in liver transplant [J].

Di Maira, Tommaso ;

Coelho Little, Ester ;

Berenguer, Marina .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2020, 46-47

[9]

EMA European Medicines Agency, 2020, AdvagrafSummary of Product Characteristics

[10] Associations of proton pump inhibitors and hospitalization due to hyponatremia: A population-based case-control study [J].

Falhammar, Henrik ;

Lindh, Jonatan D. ;

Calissendorff, Jan ;

Skov, Jakob ;

Nathanson, David ;

Mannheimer, Buster .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2019, 59 :65-69

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