Epigenetic predictors of species maximum life span and other life-history traits in mammals

被引：6

作者：

Li, Caesar Z. ^{[1
,2
,3
]}

Haghani, Amin ^{[3
,4
]}

Yan, Qi ^{[1
,4
]}

Lu, Ake T. ^{[3
,4
]}

Zhang, Joshua ^{[3
,5
]}

Fei, Zhe ^{[1
,6
]}

Ernst, Jason ^{[7
]}

Yang, X. William ^{[8
,9
]}

Gladyshev, Vadim N. ^{[10
]}

Robeck, Todd R. ^{[11
]}

Chavez, Andreas S. ^{[12
,13
]}

Cook, Joseph A. ^{[14
,15
]}

Dunnum, Jonathan L. ^{[14
,15
]}

Raj, Ken ^{[16
]}

Seluanov, Andrei ^{[17
]}

Gorbunova, Vera ^{[17
]}

Horvath, Steve ^{[1
,3
,4
,16
]}

机构：

[1] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA

[2] Johnson & Johnson Innovat Med, Spring House, PA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[4] Altos Labs, San Diego, CA 92121 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA

[6] Univ Calif Riverside, Dept Stat, Riverside, CA USA

[7] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA USA

[8] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA USA

[9] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA

[10] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA USA

[11] SeaWorld Pk & Entertainment Inc, Zool Operat, Orlando, FL USA

[12] Ohio State Univ, Dept Evolut Ecol & Organismal Biol, Columbus, OH USA

[13] Ohio State Univ, Translat Data Analyt Inst, Columbus, OH USA

[14] Univ New Mexico, Dept Biol, Albuquerque, NM USA

[15] Univ New Mexico, Museum Southwestern Biol, Albuquerque, NM USA

[16] Altos Labs, Cambridge, England

[17] Univ Rochester, Dept Biol & Med, Rochester, NY USA

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 23期

基金：

美国国家卫生研究院;

关键词：

SEX-DIFFERENCES; MICE; MECHANISMS; AMELIORATION; LONGEVITY; AGE;

D O I：

10.1126/sciadv.adm7273

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By analyzing 15,000 samples from 348 mammalian species, we derive DNA methylation (DNAm) predictors of maximum life span (R = 0.89), gestation time (R = 0.96), and age at sexual maturity (R = 0.85). Our maximum life-span predictor indicates a potential innate longevity advantage for females over males in 17 mammalian species including humans. The DNAm maximum life-span predictions are not affected by caloric restriction or partial reprogramming. Genetic disruptions in the somatotropic axis such as growth hormone receptors have an impact on DNAm maximum life span only in select tissues. Cancer mortality rates show no correlation with our epigenetic estimates of life-history traits. The DNAm maximum life-span predictor does not detect variation in life span between individuals of the same species, such as between the breeds of dogs. Maximum life span is determined in part by an epigenetic signature that is an intrinsic species property and is distinct from the signatures that relate to individual mortality risk.

引用

页数：15

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