The roles of B cells in cardiovascular diseases

被引：1
作者：
Ma, Jian [1 ]
Wang, Xiaotong [3 ]
Jia, Yuewang [1 ]
Tan, Fangyan [2 ]
Yuan, Xin [2 ]
Du, Jianlin [1 ]
机构：
[1] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China
[2] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, 74 Lin Jiang Rd, Chongqing 4000L0, Peoples R China
[3] Chongqing Med Univ, Dept Pediat, Childrens Hosp, Chongqing, Peoples R China
来源：
MOLECULAR IMMUNOLOGY | 2024年 / 171卷
基金：
中国国家自然科学基金;
关键词：
B cells; Cardiac remodeling; Fibrosis; Heart diseases; Therapy; MYOCARDIAL-INFARCTION; HEART-FAILURE; DILATED CARDIOMYOPATHY; HUMORAL IMMUNITY; CARDIAC-FUNCTION; ATHEROSCLEROSIS; INFLAMMATION; FIBROSIS; LYMPHOCYTES; TNF;
D O I：
10.1016/j.molimm.2024.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGF beta 1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.
引用
收藏
页码：36 / 46
页数：11
相关论文
共 119 条
  • [51] Artemisinin attenuates IgM xenoantibody production via inhibition of T cell-independent marginal zone B cell proliferation
    Liu, Lihua
    Zhao, Juanzhi
    Li, An
    Yang, Xuan
    Sprangers, Ben
    Li, Shengqiao
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2021, 109 (03) : 583 - 591
  • [52] ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies
    Lorenzo, Cristina
    Delgado, Pilar
    Busse, Christian E.
    Sanz-Bravo, Alejandro
    Martos-Folgado, Inmaculada
    Bonzon-Kulichenko, Elena
    Ferrarini, Alessia
    Gonzalez-Valdes, Ileana B.
    Mur, Sonia M.
    Roldan-Montero, Raquel
    Martinez-Lopez, Diego
    Martin-Ventura, Jose L.
    Vazquez, Jesus
    Wardemann, Hedda
    Ramiro, Almudena R.
    [J]. NATURE, 2021, 589 (7841) : 287 - +
  • [53] Identification of Novel Targets for Treatment of Dilated Cardiomyopathy Based on the Ferroptosis and Immune Heterogeneity
    Lu, Hongyu
    Xie, Yun
    Zhou, Ziyou
    Hong, Peijian
    Chen, Jiyan
    [J]. JOURNAL OF INFLAMMATION RESEARCH, 2023, 16 : 2461 - 2476
  • [54] The absence of B cells disrupts splenic and myocardial Treg homeostasis in coxsackievirus B3-induced myocarditis
    Lu, Jing
    Cen, Zhihong
    Tang, Quan
    Dong, Jingwei
    Qin, Lin
    Wu, Weifeng
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2022, 208 (01) : 1 - 11
  • [55] Rituximab prevents and reverses cardiac remodeling by depressing B cell function in mice
    Ma, Xiao-Lei
    Lin, Qiu-Yue
    Wang, Lei
    Xie, Xin
    Zhang, Yun-Long
    Li, Hui-Hua
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2019, 114
  • [56] Inflammation in Myocardial Diseases
    Marchant, David J.
    Boyd, John H.
    Lin, David C.
    Granville, David J.
    Garmaroudi, Farshid S.
    McManus, Bruce M.
    [J]. CIRCULATION RESEARCH, 2012, 110 (01) : 126 - 144
  • [57] Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation
    Martini, Elisa
    Kunderfranco, Paolo
    Peano, Clelia
    Carullo, Pierluigi
    Cremonesi, Marco
    Schorn, Tilo
    Carriero, Roberta
    Termanini, Alberto
    Colombo, Federico Simone
    Jachetti, Elena
    Panico, Cristina
    Faggian, Giuseppe
    Fumero, Andrea
    Torracca, Lucia
    Molgora, Martina
    Cibella, Javier
    Pagiatakis, Christina
    Brummelman, Jolanda
    Alvisi, Giorgia
    Mazza, Emilia Maria Cristina
    Colombo, Mario Paolo
    Lugli, Enrico
    Condorelli, Gianluigi
    Kallikourdis, Marinos
    [J]. CIRCULATION, 2019, 140 (25) : 2089 - 2107
  • [58] Mazzone M, 2005, PANMINERVA MED, V47, P157
  • [59] Are activated B cells involved in the process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment
    Mo, Fanrui
    Luo, Ying
    Yan, Yuluan
    Li, Juan
    Lai, Shayi
    Wu, Weifeng
    [J]. BMC CARDIOVASCULAR DISORDERS, 2021, 21 (01)
  • [60] Critical roles of inflammation in atherosclerosis
    Moriya, Junji
    [J]. JOURNAL OF CARDIOLOGY, 2019, 73 (1-2) : 22 - 27
12345678910