The roles of B cells in cardiovascular diseases

被引：1
作者：
Ma, Jian [1 ]
Wang, Xiaotong [3 ]
Jia, Yuewang [1 ]
Tan, Fangyan [2 ]
Yuan, Xin [2 ]
Du, Jianlin [1 ]
机构：
[1] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China
[2] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, 74 Lin Jiang Rd, Chongqing 4000L0, Peoples R China
[3] Chongqing Med Univ, Dept Pediat, Childrens Hosp, Chongqing, Peoples R China
来源：
MOLECULAR IMMUNOLOGY | 2024年 / 171卷
基金：
中国国家自然科学基金;
关键词：
B cells; Cardiac remodeling; Fibrosis; Heart diseases; Therapy; MYOCARDIAL-INFARCTION; HEART-FAILURE; DILATED CARDIOMYOPATHY; HUMORAL IMMUNITY; CARDIAC-FUNCTION; ATHEROSCLEROSIS; INFLAMMATION; FIBROSIS; LYMPHOCYTES; TNF;
D O I：
10.1016/j.molimm.2024.05.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGF beta 1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.
引用
收藏
页码：36 / 46
页数：11
相关论文
共 119 条
  • [1] The Emerging Role of B Lymphocytes in Cardiovascular Disease
    Adamo, Luigi
    Rocha-Resende, Cibele
    Mann, Douglas L.
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, VOL 38, 2020, 38 : 99 - 121
  • [2] Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart
    Adamo, Luigi
    Rocha-Resende, Cibele
    Lin, Chieh-Yu
    Evans, Sarah
    Williams, Jesse
    Dun, Hao
    Li, Wenjun
    Mpoy, Cedric
    Andhey, Prabhakar S.
    Rogers, Buck E.
    Lavine, Kory
    Kreisel, Daniel
    Artyomov, Maxim
    Randolph, Gwendalyn J.
    Mann, Douglas L.
    [J]. JCI INSIGHT, 2020, 5 (03)
  • [3] Modulation of subsets of cardiac B lymphocytes improves cardiac function after acute injury
    Adamo, Luigi
    Staloch, Lora J.
    Rocha-Resende, Cibele
    Matkovich, Scot J.
    Jiang, Wenlong
    Bajpai, Geetika
    Weinheimer, Carla J.
    Kovacs, Attila
    Schilling, Joel D.
    Barger, Philip M.
    Bhattacharya, Deepta
    Mann, Douglas L.
    [J]. JCI INSIGHT, 2018, 3 (11):
  • [4] Lung-resident memory B cells protect against bacterial pneumonia
    Barker, Kimberly A.
    Etesami, Neelou S.
    Shenoy, Anukul T.
    Arafa, Emad I.
    de Ana, Carolina Lyon
    Smith, Nicole M. S.
    Martin, Ian M. C.
    Goltry, Wesley N.
    Barron, Alexander M. S.
    Browning, Jeffrey L.
    Kathuria, Hasmeena
    Belkina, Anna C.
    Guillon, Antoine
    Zhong, Xuemei
    Crossland, Nicholas A.
    Jones, Matthew R.
    Quinton, Lee J.
    Mizgerd, Joseph P.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (11)
  • [5] Role of B lymphocytes in the infarcted mass in patients with acute myocardial infarction
    Casarotti, Ana C. A.
    Teixeira, Daniela
    Longo-Maugeri, Ieda M.
    Ishimura, Mayari E.
    Coste, Maria E. R.
    Bianco, Henrique T.
    Moreira, Flavio T.
    Bacchin, Amanda F.
    Izar, Maria C.
    Goncalves, Iran, Jr.
    Caixeta, Adriano
    Szarf, Gilberto
    Pinto, Ibraim M.
    Fonseca, Francisco A.
    [J]. BIOSCIENCE REPORTS, 2021, 41 (02)
  • [6] Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension
    Chan, Christopher T.
    Sobey, Christopher G.
    Lieu, Maggie
    Ferens, Dorota
    Kett, Michelle M.
    Diep, Henry
    Kim, Hyun Ah
    Krishnan, Shalini M.
    Lewis, Caitlin V.
    Salimova, Ekaterina
    Tipping, Peter
    Vinh, Antony
    Samuel, Chrishan S.
    Peter, Karlheinz
    Guzik, Tomasz J.
    Kyaw, Tin S.
    Toh, Ban-Hock
    Bobik, Alexander
    Drummond, Grant R.
    [J]. HYPERTENSION, 2015, 66 (05) : 1023 - 1033
  • [7] Class switching and high-affinity immunoglobulin G production by B cells is dispensable for the development of hypertension in mice
    Chen, Yuhan
    Dale, Bethany L.
    Alexander, Matthew R.
    Xiao, Liang
    Ao, Mingfang
    Pandey, Arvind K.
    Smart, Charles D.
    Davis, Gwendolyn K.
    Madhur, Meena S.
    [J]. CARDIOVASCULAR RESEARCH, 2021, 117 (04) : 1217 - 1228
  • [8] IL-6 trans-signalling contributes to aldosterone-induced cardiac fibrosis
    Chou, Chia-Hung
    Hung, Chi-Sheng
    Liao, Che-Wei
    Wei, Lin-Hung
    Chen, Ching-Way
    Shun, Chia-Tung
    Wen, Wen-Fen
    Wan, Cho-Hua
    Wu, Xue-Ming
    Chang, Yi-Yao
    Wu, Vin-Cent
    Wu, Kwan-Dun
    Lin, Yen-Hung
    [J]. CARDIOVASCULAR RESEARCH, 2018, 114 (05) : 690 - 702
  • [9] Cell-mediated immune response in megacolon from patients with chronic Chagas' disease
    Corbett, CEP
    Ribeiro, U
    Prianti, MDG
    Habr-Gama, A
    Okumara, M
    Gama-Rodrigues, J
    [J]. DISEASES OF THE COLON & RECTUM, 2001, 44 (07) : 993 - 998
  • [10] Full Expression of Cardiomyopathy Is Partly Dependent on B-Cells: A Pathway That Involves Cytokine Activation, Immunoglobulin Deposition, and Activation of Apoptosis
    Cordero-Reyes, Andrea M.
    Youker, Keith A.
    Trevino, Alejandro R.
    Celis, Rene
    Hamilton, Dale J.
    Flores-Arredondo, Jose H.
    Orrego, Carlos M.
    Bhimaraj, Arvind
    Estep, Jerry D.
    Torre-Amione, Guillermo
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (01): : 1 - 12
12345678910