Synthetic Methods of Quinoxaline Derivatives and their Potential Anti-inflammatory Properties

被引:1
作者
Anjali, Payal [1 ]
Kamboj, Payal [1 ]
Amir, Mohammad [1 ]
机构
[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut Chem, New Delhi 110062, India
关键词
quinoxaline; synthetic methods; anti-inflammatory; structure activity relationship; COX; p38 alpha MAPK; cytokines inhibitors; ONE-POT SYNTHESIS; IONIC LIQUID; HETEROGENEOUS CATALYST; OXIDATIVE CYCLIZATION; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; EFFICIENT; INFLAMMATION; INHIBITORS; DRUGS;
D O I
10.2174/0113895575307480240610055622
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Quinoxaline molecule has gathered great attention in medicinal chemistry due to its vide spectrum of biological activities and has emerged as a versatile pharmacophore in drug discovery and development. Its structure comprises a bicyclic ring of benzopyrazine and displays a range of pharmacological properties, including antibacterial, antifungal, antiviral, anticancer, and anti-inflammatory. This study aims to summarize the different strategies for the synthesis of quinoxalines and their anti-inflammatory properties acting through different mechanisms. Structure-activity relationships have also been discussed in order to determine the effect of structural modifications on anti-inflammatory potential. These analyses illuminate critical structural features required for optimal activity, driving the design and synthesis of new quinoxaline analogues with better anti-inflammatory activities. The anti-inflammatory properties of quinoxalines are attributed to their inhibitory action on the expression of several inflammatory modulators such as cyclooxygenase, cytokines, nuclear factor kappa-light-chain-enhancer of activated B cells (NF kappa B) and p38 alpha Mitogen Activated Protein Kinase (p38 alpha MAPK). Activators of nuclear factor erythroid 2-related factor 2 (NRF2) and agonistic effect on opioid receptors have also been discussed. Hence, this study may provide a future template for the design and development of novel quinoxaline derivatives acting through different molecular targets as potential anti-inflammatory agents with better efficacy and safety profiles.
引用
收藏
页码:138 / 162
页数:25
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