Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review and Meta-Analysis

被引：2
作者：
Soltani, Setareh [1 ]
Zahedi, Ahora [2 ]
Vergara, April Joy S. [3 ]
Noli, Marta [3 ]
Soltysik, Fumie Mitani [3 ]
Pociot, Flemming [3 ,4 ]
Yarani, Reza [3 ]
机构：
[1] Kermanshah Univ Med Sci, Taleghani & Imam Ali Hosp, Clin Res Dev Ctr, Kermanshah, Iran
[2] Iran Univ Med Sci, Fac Adv Technol Med, Dept Artificial Intelligence Med Sci, Tehran, Iran
[3] Steno Diabet Ctr Copenhagen, Dept Clin Res, Translat Type 1 Diabet Res, Herlev, Denmark
[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
来源：
STEM CELL REVIEWS AND REPORTS | 2024年 / 20卷 / 08期
关键词：
Extracellular vesicles; Adipose tissue-derived mesenchymal stem cells; Exosome; Diabetic wound; Wound healing; Meta-analysis; STEM-CELLS; FOOT ULCERS; EXOSOMES; BIOLOGY; IMPACT;
D O I：
10.1007/s12015-024-10753-z
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Extracellular vesicles isolated from adipose tissue-derived mesenchymal stromal/stem cells (ADSC-EVs) have demonstrated promising potential in wound healing treatment. To determine the therapeutic efficacy of ADSC-EVs for diabetic wounds in preclinical models, we performed a meta-analysis of available studies. PubMed and Embase were searched (to April 23, 2023). All full-text articles describing the therapeutic application of ADSC-EVs in diabetic wounds were included. Study outcomes were pooled using a random effects meta-analysis, including wound closure, angiogenesis, and collagen deposition. Other outcomes were only discussed descriptively. Seventy unique records were identified from our search; 20 full-text articles were included for qualitative analysis. Twelve studies were eligible for quantitative meta-analysis. The results showed that ADSC-EVs accelerated diabetic wound healing compared to controls with a large effect (standardized mean difference (SMD) 4.22, 95% confidence interval (CI) 3.07 to 5.36). The administration of ADSC-EVs also improved neovascularization (SMD 9.27, 95% CI 4.70 to 13.83) and collagen deposition (SMD 2.19, 95% CI 0.94 to 3.44), with a large effect. The risk of bias was unclear in all included studies. Conclusively, ADSC-EV is an effective treatment for diabetic wounds in preclinical trials, and it appears justified for transfer into the clinical field.
引用
收藏
页码：2016 / 2031
页数：16
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