Indicators of cure for women living after uterine and ovarian cancers: a population-based study

被引：2

作者：

Giudici, Fabiola ^{[1
]}

De Paoli, Angela

Toffolutti, Federica ^{[1
]}

Guzzinati, Stefano ^{[2
]}

Francisci, Silvia ^{[3
]}

Bucchi, Lauro ^{[4
]}

Gatta, Gemma ^{[5
]}

Demuru, Elena ^{[6
]}

Mallone, Sandra ^{[3
]}

Cin, Antonella Dal ^{[2
]}

Caldarella, Adele ^{[7
]}

Cuccaro, Francesco ^{[8
]}

Migliore, Enrica ^{[9
,10
]}

Gambino, Maria Letizia ^{[11
]}

Ravaioli, Alessandra ^{[4
]}

Puppo, Antonella ^{[12
]}

Ferrante, Margherita ^{[13
]}

Carrozzi, Giuliano ^{[14
]}

Stracci, Fabrizio ^{[15
]}

Musolino, Antonino ^{[16
]}

Gasparotti, Cinzia ^{[17
]}

Cavallo, Rossella ^{[18
]}

Mazzucco, Walter ^{[19
]}

Vitale, Maria Francesca ^{[20
]}

Cascone, Giuseppe ^{[21
,27
]}

Ballotari, Paola ^{[22
]}

Ferretti, Stefano ^{[23
,24
]}

Mangone, Lucia ^{[25
]}

Rizzello, Roberto Vito ^{[26
]}

Sampietro, Giuseppe

Mian, Michael ^{[28
]}

Boschetti, Lorenza ^{[29
]}

Galasso, Rocco ^{[30
]}

Bella, Francesca ^{[31
]}

Piras, Daniela ^{[32
]}

Sessa, Alessandra ^{[33
]}

Seghini, Pietro ^{[34
]}

Fanetti, Anna Clara ^{[35
]}

Pinna, Pasquala ^{[36
]}

De Angelis, Roberta

Serraino, Diego ^{[1
]}

Dal Maso, Luigino ^{[1
]}

机构：

[1] Ctr Riferimento Oncol Aviano CRO IRCCS, Canc Epidemiol Unit, Via Franco Gallini 2, I-33081 Aviano, Italy

[2] Azienda Zero, Epidemiol Dept, Padua, Italy

[3] Natl Inst Hlth, Natl Ctr Dis Prevent & Hlth Promot, I-00161 Rome, Italy

[4] IRCCS Ist Romagnolo Studio Tumori IRST Dino Amador, Romagna Unit, Emilia Romagna Canc Registry, I-47121 Meldola, Forli, Italy

[5] Fdn IRCCS Ist Nazl Tumori Milano, Dept Res, Evaluat Epidemiol Unit, I-20133 Milan, Italy

[6] Natl Inst Hlth, Dept Oncol & Mol Med, I-00161 Rome, Italy

[7] Inst Canc Res Prevent & Clin Network, Tuscany Canc Registry, I-50139 Florence, Italy

[8] Local Hlth Unit Barletta Andria Trani, Sect Canc Registry Puglia, Sect Canc Registry Puglia, I-76121 Barletta, Italy

[9] Ctr Riferimento Epidemiol & Prevenz Oncolog CPO Pi, Piedmont Canc Registry, I-10123 Turin, Italy

[10] Univ Turin, I-10123 Turin, Italy

[11] SS Epidemiol Registri Specializzati & Reti Patol, Registro Tumori ATS Insubria Prov Como & Varese, I-21100 Varese, Italy

[12] IRCCS Osped Policlin San Martino, Liguria Canc Registry, I-16132 Genoa, Italy

[13] Igiene Ospedaliera, Azienda Ospedaliero Universitaria Policlin G Rodol, I-95123 Catania, Enna, Italy

[14] Local Hlth Author, Publ Hlth Dept, Modena Unit, Emilia Romagna Canc Registry, I-41126 Modena, Italy

[15] Univ Perugia, Dept Med & Surg, Publ Hlth Sect, Umbria Canc Registry, I-06123 Perugia, Italy

[16] Univ Hosp Parma, Parma Unit, Med Oncol Unit, Emilia Romagna Canc Registry, I-43126 Parma, Italy

[17] Registro Tumori ATS Brescia, Struttura Semplice Epidemiol, ATS Brescia, I-25124 Brescia, Italy

[18] Canc Registry Azienda Sanit Locale ASL Salerno, Dipartimento Prevenz, I-84124 Salerno, Italy

[19] Azienda Osped Univ Policlin AOUP Palermo, Clin Epidemiol & Canc Registry Unit, I-90127 Palermo, Italy

[20] Registro Tumori ASL Napoli 3 Sud, I-80031 Naples, Italy

[21] Azienda Sanit Provinciale ASP Ragusa, Dipartimento Prevenz, Registro Tumori, I-97100 Ragusa, Italy

[22] ATS Val Padana, Osservatorio Epidemiol, I-46100 Mantua, Italy

[23] Ferrara Unit, Emilia Romagna Canc Registry, Local Hlth Author, Ferrara, Italy

[24] Univ Ferrara, I-44121 Ferrara, Italy

[25] Azienda Un Sanit Locale IRCCS Reggio Emilia, Reggio Emilia Unit, Epidemiol Unit, Emilia Romagna Canc Registry, I-42122 Reggio Emilia, Italy

[26] Trento Prov Canc Registry, Unit Clin Epidemiol, I-38123 Trento, Italy

[27] Agenzia Tutela Salute, Bergamo Canc Registry, Epidemiol Serv, I-24121 Bergamo, Italy

[28] Lehrkrankenhaus Paracelsus Med Privatuniversitat, Innovat Res & Teaching Serv SABES ASDAA, I-39100 Bolzano, Italy

[29] Canc Registry Prov Pavia, I-27200 Pavia, Italy

[30] IRCCS Ctr Riferimento Oncol Basilicata CROB, Unit Reg Canc Registry, Clin Epidemiol & Biostat, I-85028 Rionero In Vulture, Italy

[31] Prov Hlth Author Siracusa, Siracusa Canc Registry, I-96100 Siracusa, Italy

[32] ASL, Nord Sardegna Canc Registry, I-07100 Sassari, Italy

[33] Monitoraggio Rischio Ambientale & Registro Tumori, I-81100 Caserta, Italy

[34] AUSL Piacenza, Publ Hlth Dept, Piacenza Unit, Emilia Romagna Canc Registry, I-29100 Piacenza, Italy

[35] Agenzia Tutela Salute Montagna, Sondrio Canc Registry, I-23100 Sondrio, Italy

[36] ASL Nuoro, Serv Igiene & San Pubbl, Nuoro Canc Registry, RT Nuoro, I-08100 Nuoro, Italy

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2024年 / 193卷 / 09期

关键词：

cure fraction; time to cure; cancer prevalence; ovarian cancer; cervical cancer; corpus uteri cancer; long-term survival; mixture cure models; CERVICAL-CANCER; EUROPE; 1999-2007; SURVIVAL; PROPORTION; PREVALENCE; PROGRAMS; SITES;

D O I：

10.1093/aje/kwae044

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate net survival, cure fraction, time to cure (when 5-year conditional net survival becomes > 95%), cure prevalence (women who will not die of cancer), and already cured (living longer than time to cure). In 2018, 0.4% (121 704) of Italian women were alive after diagnosis of corpus uteri cancer, 0.2% (52 551) after cervical cancer, and 0.2% (52 153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (cure prevalence). Women with gynecological cancers have a residual excess risk of death <5% at 5 years after diagnosis. The cure fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time to cure was <= 10 years for women with gynecological cancers aged <55 years; 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were already cured. These results can contribute to improving follow-up programs for women with gynecological cancers and supporting efforts against discrimination of already cured ones. This article is part of a Special Collection on Gynecological Cancers.

引用

页码：1224 / 1232

页数：9

共 53 条

[1]

AIRTUM Working Group, 2017, EPIDEMIOL PREV, V41, P1, DOI [10.19191/EP17.2S1.P001.017, DOI 10.19191/EP17.2S1.P001.017]

[2] Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries [J].

Allemani, Claudia ;

Matsuda, Tomohiro ;

Di Carlo, Veronica ;

Harewood, Rhea ;

Matz, Melissa ;

Niksic, Maja ;

Bonaventure, Audrey ;

Valkov, Mikhail ;

Johnson, Christopher J. ;

Esteve, Jacques ;

Ogunbiyi, Olufemi J. ;

Azevedo e Silva, Gulnar ;

Chen, Wan-Qing ;

Eser, Sultan ;

Engholm, Gerda ;

Stiller, Charles A. ;

Monnereau, Alain ;

Woods, Ryan R. ;

Visser, Otto ;

Lim, Gek Hsiang ;

Aitken, Joanne ;

Weir, Hannah K. ;

Coleman, Michel P. .

LANCET, 2018, 391 (10125) :1023-1075

[3] Long-term Patterns of Excess Mortality among Endometrial Cancer Survivors [J].

Anderson, Chelsea ;

Bae-Jump, Victoria L. ;

Broaddus, Russell R. ;

Olshan, Andrew F. ;

Nichols, Hazel B. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2021, 30 (06) :1079-1088

[4] Screening and cervical cancer cure: population based cohort study [J].

Andrae, Bengt ;

Andersson, Therese M-L ;

Lambert, Paul C. ;

Kemetli, Levent ;

Silfverdal, Lena ;

Strander, Bjorn ;

Ryd, Walter ;

Dillner, Joakim ;

Tornberg, Sven ;

Sparen, Par .

BMJ-BRITISH MEDICAL JOURNAL, 2012, 344

[5]

[Anonymous], 1994, INT STAT CLASS DIS R

[6] Barriers to breast and cervical cancer screening uptake among Black, Asian, and Minority Ethnic women in the United Kingdom: evidence from a mixed-methods systematic review [J].

Bolarinwa, Obasanjo Afolabi ;

Holt, Nicole .

BMC HEALTH SERVICES RESEARCH, 2023, 23 (01)

[7] A new cure model that corrects for increased risk of non-cancer death: analysis of reliability and robustness, and application to real-life data [J].

Botta, Laura ;

Goungounga, Juste ;

Capocaccia, Riccardo ;

Romain, Gaelle ;

Colonna, Marc ;

Gatta, Gemma ;

Boussari, Olayide ;

Jooste, Valerie .

BMC MEDICAL RESEARCH METHODOLOGY, 2023, 23 (01)

[8] Clinical Epidemiology of Microinvasive Cervical Carcinoma in an Italian Population Targeted by a Screening Programme [J].

Bucchi, Lauro ;

Costa, Silvano ;

Mancini, Silvia ;

Baldacchini, Flavia ;

Giuliani, Orietta ;

Ravaioli, Alessandra ;

Vattiato, Rosa ;

Zamagni, Federica ;

Rossi, Paolo Giorgi ;

Campari, Cinzia ;

Canuti, Debora ;

de Bianchi, Priscilla Sassoli ;

Ferretti, Stefano ;

Falcini, Fabio .

CANCERS, 2022, 14 (09)

[9] Changes in the incidence of cervical tumours by disease stage in a cytology-based screening programme [J].

Bucchi, Lauro ;

Mancini, Silvia ;

Baldacchini, Flavia ;

Giuliani, Orietta ;

Ravaioli, Alessandra ;

Vattiato, Rosa ;

Falcini, Fabio ;

Rossi, Paolo Giorgi ;

Campari, Cinzia ;

Canuti, Debora ;

Di Felice, Enza ;

de Bianchi, Priscilla Sassoli ;

Ferretti, Stefano ;

Bertozzi, Nicoletta ;

Finarelli, Alba Carola ;

Naldoni, Carlo ;

Borciani, Elisabetta ;

Dataro, Pier Giorgio ;

Gatti, Giorgio ;

Lauri, Alessandro ;

Lombardozzi, Luigi ;

Paterlini, Luisa ;

Rubino, Teresa ;

Andresini, Raffaella ;

Carrozzi, Giuliano ;

Corradini, Rossella ;

Goldoni, Carlo Alberto ;

Venturelli, Agar ;

Vezzani, Maria Dirce ;

Bazzani, Carmen ;

Biavati, Patrizia ;

Cristiani, Paolo ;

Manfredi, Marilena ;

Mezzetti, Francesca ;

Pasquini, Adriana ;

Caprara, Licia ;

De Lillo, Margherita ;

Nannini, Roberto ;

Carpanelli, Maria Cristina ;

De Togni, Aldo ;

Garutti, Paola ;

Palmonari, Caterina ;

Morini, Nori ;

Schincaglia, Patrizia ;

Serafini, Monica ;

Vitali, Benedetta ;

Brunelli, Antonella ;

Farneti, Massimo ;

Imolesi, Claudia ;

Palazzi, Mauro .

JOURNAL OF MEDICAL SCREENING, 2020, 27 (02) :96-104

[10] Estimating the impact of an organised screening programme on cervical cancer incidence: A 26-year study from northern Italy [J].

Bucchi, Lauro ;

Baldacchini, Flavia ;

Mancini, Silvia ;

Ravaioli, Alessandra ;

Giuliani, Orietta ;

Vattiato, Rosa ;

Falcini, Fabio ;

Rossi, Paolo Giorgi ;

Campari, Cinzia ;

Canuti, Debora ;

Di Felice, Enza ;

de Bianchi, Priscilla Sassoli ;

Ferretti, Stefano ;

Bertozzi, Nicoletta ;

Biggeri, Annibale ;

Bertozzi, Nicoletta ;

Di Felice, Enza ;

Ferretti, Stefano ;

Finarelli, Alba Carola ;

Naldoni, Carlo ;

de Bianchi, Priscilla Sassoli ;

Baldacchini, Flavia ;

Bucchi, Lauro ;

Giuliani, Orietta ;

Mancini, Silvia ;

Ravaioli, Alessandra ;

Vattiato, Rosa ;

Falcini, Fabio ;

Borciani, Elisabetta ;

Dataro, Pier Giorgio ;

Gatti, Giorgio ;

Lauri, Alessandro ;

Lombardozzi, Luigi ;

Michiara, Maria ;

Mangone, Lucia ;

Campari, Cinzia ;

Paterlini, Luisa ;

Rubino, Teresa ;

Andresini, Raffaella ;

Carrozzi, Giuliano ;

Corradini, Rossella ;

Goldoni, Carlo Alberto ;

Venturelli, Agar ;

Vezzani, Maria Dirce ;

Bazzani, Carmen ;

Biavati, Patrizia ;

Cristiani, Paolo ;

Manfredi, Marilena ;

Mezzetti, Francesca ;

Pasquini, Adriana .

INTERNATIONAL JOURNAL OF CANCER, 2019, 144 (05) :1017-1026

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