Transforming our understanding of species-specific gene regulation

被引：0
|
作者：
Dennis, Megan Y. [1 ,2 ]
机构：
[1] Univ Calif Davis, Genome Ctr, Dept Biochem & Mol Med, Davis, CA 95616 USA
[2] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA
来源：
CELL GENOMICS | 2024年 / 4卷 / 04期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
CIS; EVOLUTION;
D O I：
10.1016/j.xgen.2024.100540
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mechanisms underlying phenotypic divergence across species remain unresolved. In this issue of Cell Genomics , Hansen, Fong, et al. 1 systematically dissect human and rhesus macaque gene expression divergence by screening tens of thousands of orthologous elements for enhancer activity in lymphoblastoid cell lines, revealing a much greater role for trans divergence at levels equal to those of cis effects, counter to the prevailing consensus in the field.
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页数：2
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