Efficient C(sp3)-P(v) bond cleavage and reconstruction of free α-aminophosphonates via palladium catalysis

被引：1

作者：

Yi, Li-Na ^{[1
]}

Bu, Jinghan ^{[1
]}

Zhao, Tao ^{[1
]}

Huang, Mengyi ^{[1
]}

Yang, Qiang ^{[1
]}

机构：

[1] Southwest Minzu Univ, Coll Chem & Environm, Key Lab Gen Chem Natl Ethn Affairs Commiss, Chengdu 610041, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 81期

基金：

中国国家自然科学基金;

关键词：

CARBON-PHOSPHORUS BOND; C-P; TRANSITION; FUNCTIONALIZATION; METATHESIS;

D O I：

10.1039/d4cc03702b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transition metal-catalyzed cleavage and reconstruction of the C-P bond provides a highly efficient and rapid method for the transformation of organophosphine compounds. In this study, a novel and general protocol for the palladium-catalyzed C(sp(3))-P(V) bond cleavage of free alpha-aminophosphonates and subsequent functionalization via C-P bond recombination has been developed. The reaction exhibits high reactivity between the C(sp(3))-P bond and halides, accommodating a wide range of substrates and enabling the rapid synthesis of aryl, alkenyl, and alkyl organophosphine molecules. Additionally, the synthetic utility is validated by gram-scale synthesis, and the reaction process is corroborated by mechanistic experiments.

引用

页码：11512 / 11515

页数：4