Chronic Hepatitis B and Hepatitis D Virus Infection

被引：1

作者：

Rusignuolo, Giuseppe ^{[1
,2
]}

Thimme, Robert ^{[1
]}

Neumann-Haefelin, Christoph ^{[1
,2
]}

机构：

[1] Uni Klin Freiburg, Klin Innere Med 2, Freiburg, Germany

[2] Gerok Leberzentrum, Freiburg, Germany

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2024年 / 149卷 / 16期

关键词：

Hepatitis-B-Virus; Hepatitis-D-Virus; Therapie; antiviral; Entecavir; Tenofovir; Bulevirtid; hepatitis B virus; hepatitis D virus; therapy; entecavir; tenofovir; bulevirtide; BULEVIRTIDE; EFFICACY; PHASE-3; SAFETY; TRIAL;

D O I：

10.1055/a-2057-1840

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eine unbehandelte chronische Hepatitis-B-Virus-Infektion kann bis zur Leberzirrhose und zum hepatozellul & auml;ren Karzinom fortschreiten, was durch eine rechtzeitige Diagnose und eine antivirale Therapie verhindert werden kann. Eine Heilung ist bisher aber in der Regel nicht m & ouml;glich. Eine Koinfektion mit dem Hepatitis-D-Virus erh & ouml;ht das Risiko einer Leberzirrhose. Auch f & uuml;r die Hepatitis D steht inzwischen eine effektive Therapie zur Verf & uuml;gung. About 0,5% of the population in Germany has a chronic hepatitis B virus (HBV) infection. Untreated, chronic HBV infection can progress to liver cirrhosis and hepatocellular carcinoma (HCC). If diagnosed early, antiviral therapy can effectively prevent liver disease progression, but a cure is currently hardly achievable. About 5% of those chronically infected with HBV are also co-infected with the hepatitis D virus (HDV). HBV/HDV co-infection leads to liver cirrhosis in approximately 50% of patients within 5-10 years. Since 2020, the cell entry inhibitor bulevirtide is available as a specific therapy for HBV/HDV co-infection.

引用

页码：948 / 954

页数：7

共 24 条

[1] A case of HBV-induced liver failure in the REEF-2 phase II trial: Implications for finite treatment strategies in HBV 'cure' [J].

Agarwal, Kosh ;

Lok, James ;

Carey, Ivana ;

Shivkar, Yatin ;

Biermer, Michael ;

Berg, Thomas ;

Lonjon-Domanec, Isabelle .

JOURNAL OF HEPATOLOGY, 2022, 77 (01) :245-248

[2] A 3-year course of bulevirtide monotherapy may cure HDV infection in patients with cirrhosis [J].

Anolli, Maria Paola ;

Degasperi, Elisabetta ;

Allweiss, Lena ;

Sangiovanni, Angelo ;

Maggioni, Marco ;

Scholtes, Caroline ;

Oberhardt, Valerie ;

Neumann-Haefelin, Christoph ;

Dandri, Maura ;

Zoulim, Fabien ;

Lampertico, Pietro .

JOURNAL OF HEPATOLOGY, 2023, 78 (04) :876-880

[3] Hepatitis D Virus Infection [J].

Asselah, Tarik ;

Rizzetto, Mario .

NEW ENGLAND JOURNAL OF MEDICINE, 2023, 389 (01) :58-70

[4]

Biallas RSG., 2023, Epid Bull, V31, P3, DOI [10.25646/11669, DOI 10.25646/11669]

[5] S3 Guideline of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) for the Prophylaxis, Diagnosis and Therapy of Hepatitis B Virus Infection (AWMF Register No. 021-11) [J].

Cornberg, Markus ;

Sandmann, Lisa ;

Protzer, Ulrike ;

Niederau, Claus ;

Tacice, Frank ;

Berg, Thomas ;

Glebe, Dieter ;

Jilg, Wolfgang ;

VVedemeyer, Heiner ;

VVirth, Stefan ;

Siederdissen, Christoph Hoener zu ;

Lynen-Jansen, Petra ;

van Leeuwen, Pia ;

Petersen, Joerg ;

Ciesek, Sandra ;

Timm, Joerg ;

Knop, Viola ;

Schirrnacher, Peter ;

Schuettler, Christian ;

Buggisch, Peter ;

Tannapfel, Andrea ;

Jochum, Christoph ;

Hinrichsen, Holger ;

Kautz, Achim ;

Peiffer, Kai-Henrik ;

Sarrazin, Christoph ;

Schott, Eckart ;

Dikopoulos, Nektarios ;

Kroy, Daniela ;

Sprinzl, Martin ;

van Bornmel, Florian ;

van Thiel, Ingo ;

Vermehren, Johannes ;

Wursthorn, Karsten ;

Zeuzem, Stefan ;

Manns, Michael P. ;

Berg, Christoph ;

Herzer, Kerstin ;

Maasoumy, Benjamin ;

Sterneck, Martina ;

Aehling, Niklas ;

Trowe, Eqbert ;

Strassburg, Christian ;

Gerlich, Wolfram ;

Kallinowski, Birgit ;

zur Wiesch, Julian Schulze ;

Verheyen, Jens ;

Wicker, Sabine ;

Wranlce, Anika ;

Klinker, Hartwig .

ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2021, 59 (07) :691-776

[6] Hepatocellular Carcinoma Surveillance Patterns and Outcomes in Patients With Cirrhosis [J].

Daher, Darine ;

El Dahan, Karim Seif ;

Cano, Alva ;

Gonzales, Michael ;

Ransom, Crystal ;

Jaurez, Erik ;

Carranza, Osiris ;

Quirk, Lisa ;

Morgan, Todd ;

Gopal, Purva ;

Patel, Madhukar S. ;

Lieber, Sarah ;

Louissaint, Jeremy ;

Cotter, Thomas G. ;

Vanwagner, Lisa B. ;

Yang, Ju Dong ;

Parikh, Neehar D. ;

Yopp, Adam ;

Rich, Nicole E. ;

Singal, Amit G. .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2024, 22 (02) :295-304

[7] Bulevirtide-based treatment strategies for chronic hepatitis delta: A review [J].

Degasperi, Elisabetta ;

Anolli, Maria Paola ;

Lampertico, Pietro .

JOURNAL OF VIRAL HEPATITIS, 2023, 30 :26-32

[8]

Dietz-Fricke C, 2023, J HEPATOL, V78, pS108

[9] Treating hepatitis D with bulevirtide-Real-world experience from 114 patients [J].

Dietz-Fricke, Christopher ;

Tacke, Frank ;

Zollner, Caroline ;

Demir, Munevver ;

Schmidt, Hartmut H. ;

Schramm, Christoph ;

Willuweit, Katharina ;

Lange, Christian M. ;

Weber, Sabine ;

Denk, Gerald ;

Berg, Christoph P. ;

Grottenthaler, Julia M. ;

Merle, Uta ;

Olkus, Alexander ;

Zeuzem, Stefan ;

Sprinzl, Kathrin ;

Berg, Thomas ;

van Bommel, Florian ;

Wiegand, Johannes ;

Herta, Toni ;

Seufferlein, Thomas ;

Zizer, Eugen ;

Dikopoulos, Nektarios ;

Thimme, Robert ;

Neumann-Haefelin, Christoph ;

Galle, Peter R. ;

Sprinzl, Martin ;

Lohse, Ansgar W. ;

zur Wiesch, Julian Schulze ;

Kempski, Jan ;

Geier, Andreas ;

Reiter, Florian P. ;

Schlevogt, Bernhard ;

Goediker, Juliana ;

Hofmann, Wolf Peter ;

Buggisch, Peter ;

Kahlhofer, Julia ;

Port, Kerstin ;

Maasoumy, Benjamin ;

Cornberg, Markus ;

Wedemeyer, Heiner ;

Deterding, Katja .

JHEP REPORTS, 2023, 5 (04)

[10] EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection [J].

Lampertico P. ;

Agarwal K. ;

Berg T. ;

Buti M. ;

Janssen H.L.A. ;

Papatheodoridis G. ;

Zoulim F. ;

Tacke F. .

JOURNAL OF HEPATOLOGY, 2017, 67 (02) :370-398

← 1 2 3 →