Gold-catalyzed intermolecular tandem cyclization/[4+3] cycloaddition of 2-(1-alkynyl)-cyclopropyl pyridines with nitrones: an efficient strategy for the synthesis of [1,2]oxazepino[5,4-a] indolizines

被引：1

作者：

Rao, Fucai ^{[1
]}

Cheng, Meng ^{[1
]}

Hu, Zhiwei ^{[1
]}

Chen, Xinyi ^{[1
]}

Zhao, Suyang ^{[1
]}

Chen, Zuliang ^{[1
,2
]}

机构：

[1] Yichun Univ, Coll Chem & Bioengn, Yichun 336000, Peoples R China

[2] Yichun Univ, Key Lab Jiangxi Univ Appl Chem & Chem Biol, Yichun 336000, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 13期

基金：

中国国家自然科学基金;

关键词：

1,3-DIPOLAR CYCLOADDITION; 1-(1-ALKYNYL)CYCLOPROPYL KETONES; MODULAR ENTRY; CYCLIZATION; 2-(2-ENYNYL)PYRIDINES; CYCLOBUTANES; DERIVATIVES; DISCOVERY; PYRROLES; ACCESS;

D O I：

10.1039/d4qo00580e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient approach is described for the diastereoselective synthesis of [1,2]oxazepino[5,4-a] indolizines via a gold-catalyzed [4 + 3] cycloaddition reaction of 2-(1-alkynyl)-cyclopropyl pyridine with nitrones. This methodology has great potential to construct seven-membered heterocycle-fused indolizine scaffolds from simple building blocks. Based on our preliminary results, a probable mechanism for this reaction pathway has been proposed.

引用

页码：3685 / 3691

页数：7

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