The emerging role of brain neuroinflammatory responses in Alzheimer's disease

被引：6
作者：
Amelimojarad, Mandana [1 ]
Amelimojarad, Melika [1 ]
Cui, Xiaonan [1 ]
机构：
[1] Dalian Med Univ, Dept Oncol, Affiliated Hosp 1, Dalian, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2024年 / 16卷
关键词：
neuroinflammation; Alzheimer's disease; microglia; NSAIDs; inflammation; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NF-KAPPA-B; AMYLOID-BETA; MICROGLIAL ACTIVATION; MOUSE MODEL; CEREBROSPINAL-FLUID; COGNITIVE DEFICITS; APOLIPOPROTEIN-E; INFLAMMATION; PLASMA;
D O I：
10.3389/fnagi.2024.1391517
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
As the most common cause of dementia, Alzheimer's disease (AD) is characterized by neurodegeneration and synaptic loss with an increasing prevalence in the elderly. Increased inflammatory responses triggers brain cells to produce pro-inflammatory cytokines and accelerates the A beta accumulation, tau protein hyper-phosphorylation leading to neurodegeneration. Therefore, in this paper, we discuss the current understanding of how inflammation affects brain activity to induce AD pathology, the inflammatory biomarkers and possible therapies that combat inflammation for AD.
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页数：10
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