Trends in preterm birth in women living with HIV in Switzerland over the last three decades: A multicentric, prospective, cohort study

被引:2
作者
Areta, Marina Lumbreras [1 ,10 ]
Falcone, Federico E. Migliorelli [1 ,2 ]
Rudin, Christoph [3 ]
Kahlert, Christian R. [4 ]
Paioni, Paolo [5 ]
Baumann, Marc U. [6 ]
Darling, Katharine [7 ]
Polli, Christian [8 ]
de Tejada, Begona Martinez [1 ,9 ]
机构
[1] Univ Hosp Geneva, Dept Pediat Gynecol & Obstet, Geneva, Switzerland
[2] Univ Barcelona, Hosp Clin & Hosp St Joan Deu, BCNatal Fetal Med Res Ctr, Barcelona, Spain
[3] Univ Childrens Hosp Basel, Basel, Switzerland
[4] Childrens Hosp Eastern Switzerland, Infect Dis & Hosp Epidemiol, St Gallen, Switzerland
[5] Univ Childrens Hosp Zurich, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland
[6] Bern Univ Hosp, Dept Obstet & Gynecol, Inselspital, Bern, Switzerland
[7] Lausanne Univ Hosp, Infect Dis Serv, Lausanne, Switzerland
[8] Reg Hosp, Dept Obstet & Gynecol, Lugano, Switzerland
[9] Univ Geneva, Fac Med, Geneva, Switzerland
[10] Univ Hosp Geneva, Geneva, Switzerland
关键词
antiretroviral therapy; epidemiology; HIV/AIDS; preterm birth; MATERNAL ANTIRETROVIRAL DRUGS; INFECTED WOMEN; PREMATURE DELIVERY; THERAPY; PREGNANCY; RISK; TRANSMISSION; OUTCOMES; WEIGHT; BORN;
D O I
10.1111/hiv.13652
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background HIV infection and its management during pregnancy to reduce perinatal transmission has been associated with preterm birth (PTB). This management has drastically changed. We aimed to evaluate changes in rates of PTB over 34 years in women living with HIV (WLWH) in Switzerland, and to identify factors and interventions associated with these changes. Methods We analysed data from 1238 singleton pregnancies, prospectively collected by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and the Swiss HIV Cohort Study (SHCS) between 1986 and 2020. Rates of PTB in this cohort were compared with that of the general Swiss population for three time periods according to changing treatment strategies recommended at the time. We evaluated the association of PTB with sociodemographic, HIV infection and obstetric variables in uni- and multivariate logistic regression. Results Rate of PTB in WLWH was highest prior to 2010 (mean 20.4%), and progressively decreased since then (mean 11.3%), but always remained higher than in the general population (5%). Older maternal age, lower CD4 count and detectable viraemia at third trimester (T3), drug consumption and mode of delivery were all significantly associated with both PTB and period of study in univariate analysis. There was no association between PTB and type of antiretroviral regimen. No difference was found in the rate of spontaneous labor between PTB and term delivery groups. Only higher CD4 count at T3 and vaginal delivery were significantly associated with a decrease in PTB over time in multivariate analysis. Conclusions Preterm birth in WLWH in Switzerland has drastically decreased over the last three decades, but remains twice the rate of that in the general population. Improved viral control and changes in mode of delivery (vaginal birth recommended if viral loads are low near birth) have led to this progress.
引用
收藏
页码:958 / 966
页数:9
相关论文
共 48 条
[41]   Uterocervical angle and cervical length measurements for spontaneous preterm birth prediction in low-risk singleton pregnant women: a prospective cohort study [J].
Nguyen, Trang Thi Hoang ;
Vu, Tam Van ;
Nguyen, Huy Vu Quoc .
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2024, 310 (03) :1611-1619
[42]   Association between food intake and obesity in pregnant women living with and without HIV in Cape Town, South Africa: a prospective cohort study [J].
Hlengiwe P. Madlala ;
Nelia P. Steyn ;
Emma Kalk ;
Mary-Anne Davies ;
Dorothy Nyemba ;
Thokozile R. Malaba ;
Ushma Mehta ;
Gregory Petro ;
Andrew Boulle ;
Landon Myer .
BMC Public Health, 21
[43]   Risk of spontaneous preterm birth elevated after first cesarean delivery at full dilatation: a retrospective cohort study of over 30,000 women [J].
Woolner, Andrea M. F. ;
Raja, Edwin Amalraj ;
Bhattacharya, Sohinee ;
Black, Mairead E. .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2024, 230 (03) :358.e1-358.e13
[44]   Spontaneous preterm birth risk among HPV-vaccinated and -unvaccinated women: a nationwide retrospective cohort study of over 240 000 singleton births [J].
McClymont, Elisabeth ;
Faber, Mette T. ;
Belmonte, Federica ;
Kjaer, Susanne K. .
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2023, 130 (04) :358-365
[45]   Contraceptive method switching among women living in sub-Saharan Africa participating in an HIV-1 prevention trial: a prospective cohort study [J].
Chappell, Catherine A. ;
Harkoo, Ishana ;
Szydlo, Daniel W. ;
Bunge, Katherine E. ;
Singh, Devika ;
Nakabiito, Clemensia ;
Mhlanga, Felix ;
Kamira, Betty ;
Piper, Jeanna M. ;
Balkus, Jennifer E. ;
Hillier, Sharon L. .
CONTRACEPTION, 2019, 100 (03) :214-218
[46]   Prediction of spontaneous preterm birth using CCL2 and CXCL10 in maternal serum of symptomatic high-risk pregnant women: a prospective cohort study [J].
Hoffmann, Jessica Alana ;
Gruendler, Kathleen ;
Richter, Dagmar- Ulrike ;
Stubert, Johannes .
BMC PREGNANCY AND CHILDBIRTH, 2023, 23 (01)
[47]   Prediction of spontaneous preterm birth using CCL2 and CXCL10 in maternal serum of symptomatic high-risk pregnant women: a prospective cohort study [J].
Jessica Alana Hoffmann ;
Kathleen Gründler ;
Dagmar- Ulrike Richter ;
Johannes Stubert .
BMC Pregnancy and Childbirth, 23
[48]   Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990-2019): an age-period-cohort analysis of the global burden of disease study 2019 [J].
Tang, Juan ;
Hu, Shaobo ;
Liu, Xiaozhu ;
Li, Huan ;
Kuang, Lirong ;
Zhang, Lei ;
Cao, Wenzhai ;
Zhang, Ting ;
Guan, Xiaoyan ;
Li, Lang ;
Zhang, Yutao ;
Peng, Shengxian ;
Zhang, Qingwei ;
Zhou, Xiaoqian .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2024, 11