Brain and cervical spinal cord MRI correlates of sensorimotor impairment in patients with multiple sclerosis

被引:3
作者
Morozumi, Tetsu [1 ]
Preziosa, Paolo [1 ,2 ,3 ]
Meani, Alessandro [1 ]
Pessina, Giorgia [1 ]
Pagani, Elisabetta [1 ]
Azzimonti, Matteo [1 ,2 ,3 ]
Filippi, Massimo [1 ,2 ,3 ,4 ,5 ]
Rocca, Maria A. [1 ,2 ,3 ]
机构
[1] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy
[2] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy
[3] Univ Vita Salute San Raffaele, Milan, Italy
[4] IRCCS San Raffaele Sci Inst, Neurorehabil Unit, Milan, Italy
[5] IRCCS San Raffaele Sci Inst, Neurophysiol Serv, Milan, Italy
关键词
Multiple sclerosis; MRI; spinal cord; disability; GRAY-MATTER ATROPHY; PHYSICAL-DISABILITY; ABNORMALITIES; ASSOCIATION; LESIONS;
D O I
10.1177/13524585241260145
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Cervical spinal cord (cSC) lesions and atrophy contribute to disability in multiple sclerosis (MS), but associations with specific sensorimotor dysfunction require further exploration.Objective: To investigate the associations of brain and cSC magnetic resonance imaging (MRI) measures with sensorimotor impairment in MS.Methods: One hundred fifty-one MS patients and 69 healthy controls underwent 3T MRI and clinical assessments including Expanded Disability Status Scale (EDSS), 9-hole peg test (9-HPT), finger tapping test (FTT), timed 25-foot walk test (T25FWT), and vibration detection threshold (VDT). Random forest ranked brain (T2-hyperintense lesion volume (T2-LV) and normalized deep gray matter (GM), cortical and white matter (WM) volumes) and cSC (T2-LV and total, GM, and WM cross-sectional areas (CSAs) at C2/C3 level) MRI measures relevance in explaining EDSS milestones (EDSS >= 3.0, >= 4.0, and >= 6.0), VDT, pyramidal and sensory functional systems (P-FS and S-FS >= 2), and motor tests impairment.Results: Various combinations of brain and cSC MRI measures explained EDSS milestones (area under the curve (AUC) =0.879-0.900), VDT (R2 = 0.194), and impaired P-FS (AUC = 0.820), S-FS (AUC = 0.795), 9-HPT (AUC = 0.793), FTT (AUC = 0.740), and T25FWT (AUC = 0.825). cSC GM CSA was the most informative feature for all outcomes, except 9-HPT.Conclusion: cSC MRI measures, especially GM CSA, explain EDSS and sensorimotor dysfunction better than brain measures in MS.
引用
收藏
页码:1004 / 1015
页数:12
相关论文
共 36 条
[1]   Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis [J].
Block, Valerie J. ;
Cheng, Shuiting ;
Juwono, Jeremy ;
Cuneo, Richard ;
Kirkish, Gina ;
Alexander, Amber M. ;
Khan, Mahir ;
Akula, Amit ;
Caverzasi, Eduardo ;
Papinutto, Nico ;
Stern, William A. ;
Pletcher, Mark J. ;
Marcus, Gregory M. ;
Olgin, Jeffrey E. ;
Hauser, Stephen L. ;
Gelfand, Jeffrey M. ;
Bove, Riley ;
Cree, Bruce A. C. ;
Henry, Roland G. .
MULTIPLE SCLEROSIS JOURNAL, 2023, 29 (03) :363-373
[2]   Clinical Relevance of Multiparametric MRI Assessment of Cervical Cord Damage in Multiple Sclerosis [J].
Bonacchi, Raffaello ;
Pagani, Elisabetta ;
Meani, Alessandro ;
Cacciaguerra, Laura ;
Preziosa, Paolo ;
De Meo, Ermelinda ;
Filippi, Massimo ;
Rocca, Maria A. .
RADIOLOGY, 2020, 296 (03) :605-615
[3]   Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis [J].
Ciccarelli, O. ;
Wheeler-Kingshott, C. A. ;
McLean, M. A. ;
Cercignani, M. ;
Wimpey, K. ;
Miller, D. H. ;
Thompson, A. J. .
BRAIN, 2007, 130 :2220-2231
[4]   MRI correlates of clinical disability and hand-motor performance in multiple sclerosis phenotypes [J].
Cordani, Claudio ;
Hidalgo de la Cruz, Milagros ;
Meani, Alessandro ;
Valsasina, Paola ;
Esposito, Federica ;
Pagani, Elisabetta ;
Filippi, Massimo ;
Rocca, Maria A. .
MULTIPLE SCLEROSIS JOURNAL, 2021, 27 (08) :1205-1221
[5]   Imaging correlates of hand motor performance in multiple sclerosis: A multiparametric structural and functional MRI study [J].
Cordani, Claudio ;
Meani, Alessandro ;
Esposito, Federica ;
Valsasina, Paola ;
Colombo, Bruno ;
Pagani, Elisabetta ;
Preziosa, Paolo ;
Comi, Giancarlo ;
Filippi, Massimo ;
Rocca, Maria A. .
MULTIPLE SCLEROSIS JOURNAL, 2020, 26 (02) :233-244
[6]   Spatial distribution of multiple sclerosis lesions in the cervical spinal cord [J].
Eden, Dominique ;
Gros, Charley ;
Badji, Atef ;
Dupont, Sara M. ;
De Leener, Benjamin ;
Maranzano, Josefina ;
Ren Zhuoquiong ;
Liu, Yaou ;
Granberg, Tobias ;
Ouellette, Russell ;
Stawiarz, Leszek ;
Hillert, Jan ;
Talbott, Jason ;
Bannier, Elise ;
Kerbrat, Anne ;
Edan, Gilles ;
Labauge, Pierre ;
Callot, Virginie ;
Pelletier, Jean ;
Audoin, Bertrand ;
Rasoanandrianina, Henitsoa ;
Brisset, Jean-Christophe ;
Valsasina, Paola ;
Rocca, Maria A. ;
Filippi, Massimo ;
Bakshi, Rohit ;
Tauhid, Shahamat ;
Prados, Ferran ;
Yiannakas, Marios ;
Kearney, Hugh ;
Ciccarelli, Olga ;
Smith, Seth A. ;
Treaba, Constantina Andrada ;
Mainero, Caterina ;
Lefeuvre, Jennifer ;
Reich, Daniel S. ;
Nair, Govind ;
Shepherd, Timothy M. ;
Charlson, Erik ;
Tachibana, Yasuhiko ;
Hori, Masaaki ;
Kamiya, Kouhei ;
Chougar, Lydia ;
Narayanan, Sridar ;
Cohen-Adad, Julien .
BRAIN, 2019, 142 :633-646
[7]   The Nine-Hole Peg Test as a manual dexterity performance measure for multiple sclerosis [J].
Feys, Peter ;
Lamers, Ilse ;
Francis, Gordon ;
Benedict, Ralph ;
Phillips, Glenn ;
LaRocca, Nicholas ;
Hudson, Lynn D. ;
Rudick, Richard .
MULTIPLE SCLEROSIS JOURNAL, 2017, 23 (05) :711-720
[8]  
Filippi M, 2018, NAT REV DIS PRIMERS, V4, DOI [10.1038/s41572-018-0041-4, 10.1038/s41572-018-0046-z]
[9]   Quantitative vibratory sensation measurement is related to sensory cortical thickness in MS [J].
Fritz, Nora E. ;
Eloyan, Ani ;
Glaister, Jeffrey ;
Dewey, Blake E. ;
Al-Louzi, Omar ;
Costello, M. Gabriela ;
Chen, Min ;
Prince, Jerry L. ;
Calabresi, Peter A. ;
Zackowski, Kathleen M. .
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2019, 6 (03) :586-595
[10]   Spinal Cord Neuronal Pathology in Multiple Sclerosis [J].
Gilmore, Christopher P. ;
DeLuca, Gabriele C. ;
Bo, Lars ;
Owens, Trudy ;
Lowe, James ;
Esiri, Margaret M. ;
Evangelou, Nikos .
BRAIN PATHOLOGY, 2009, 19 (04) :642-649