Chemokine Receptor 4-Targeted PET/CT With 68Ga-Pentixather Detects More Lesions Than 68Ga-Pentixafor PET/CT in Multiple Myeloma

被引：2
作者：
Yang, Qiao [1 ]
Zhang, Fujing [2 ]
Hao, Zhixin [1 ]
Zhuang, Junling [2 ,3 ]
Huo, Li [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Beijing Key Lab Mol Targeted Diag & Therapy Nucl, Peking Union Med Coll Hosp,Ctr Rare Dis Res, Dept Nucl Med,State Key Lab Complex Severe & Rare, 1 Shuaifuyuan, Beijing 100730, Peoples R China
[2] Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Hematol, Beijing, Peoples R China
[3] Peking Union Med Coll Hosp, Dept Hematol, 1 Shuaifuyuan, Beijing 100730, Peoples R China
来源：
CLINICAL NUCLEAR MEDICINE | 2024年 / 49卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Ga-68-pentixather; multiple myeloma; PET/CT; CXCR4-DIRECTED ENDORADIOTHERAPY;
D O I：
10.1097/RLU.0000000000005194
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
An 83-year-old woman with newly diagnosed multiple myeloma (MM) was enrolled in our Ga-68-pentixather and Ga-68-pentixafor PET/CT trial for evaluation of tumor burden. Ga-68-pentixather PET/CT detected more focal bone lesions, and the uptake levels of focal bone lesions on Ga-68-pentixather PET/CT were higher than those on Ga-68-pentixafor PET/CT. This suggests that Ga-68-pentixather PET/CT may be an alternative imaging modality and more sensitive in detecting MM lesions than Ga-68-pentixafor PET/CT.
引用
收藏
页码：592 / 593
页数：2
相关论文
共 8 条
  • [1] CXCR4-targeted theranostics in oncology
    Buck, Andreas K.
    Serfling, Sebastian E.
    Lindner, Thomas
    Haenscheid, Heribert
    Schirbel, Andreas
    Hahner, Stefanie
    Fassnacht, Martin
    Einsele, Hermann
    Werner, Rudolf A.
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (12) : 4133 - 4144
  • [2] Biokinetics and Dosimetry of 177Lu-Pentixather
    Haenscheid, Heribert
    Schirbel, Andreas
    Hartrampf, Philipp
    Kraus, Sabrina
    Werner, Rudolf A.
    Einsele, Hermann
    Wester, Hans-Juergen
    Lassmann, Michael
    Kortuem, Martin
    Buck, Andreas K.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2022, 63 (05) : 754 - 760
  • [3] First-in-Human Experience of CXCR4-Directed Endoradiotherapy with 177Lu- and 90Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease
    Herrmann, Ken
    Schottelius, Margret
    Lapa, Constantin
    Osl, Theresa
    Poschenrieder, Andreas
    Haenscheid, Heribert
    Lueckerath, Katharina
    Schreder, Martin
    Bluemel, Christina
    Knott, Markus
    Keller, Ulrich
    Schirbel, Andreas
    Samnick, Samuel
    Lassmann, Michael
    Kropf, Saskia
    Buck, Andreas K.
    Einsele, Hermann
    Wester, Hans-Juergen
    Knop, Stefan
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (02) : 248 - 251
  • [4] CXCR4-directed endoradiotherapy induces high response rates in extramedullary relapsed Multiple Myeloma
    Lapa, Constantin
    Herrmann, Ken
    Schirbel, Andreas
    Haenscheid, Heribert
    Luerckerath, Katharina
    Schottelius, Margret
    Kircher, Malte
    Werner, Rudolf A.
    Schreder, Martin
    Samnick, Samuel
    Kropf, Saskia
    Knop, Stefan
    Buck, Andreas K.
    Einsele, Hermann
    Wester, Hans-Juergen
    Kortuem, K. Martin
    [J]. THERANOSTICS, 2017, 7 (06): : 1589 - 1597
  • [5] [68Ga] Pentixafor-PET/CT for imaging of chemokine receptor CXCR4 expression in multiple myeloma - Comparison to [18F] FDG and laboratory values
    Lapa, Constantin
    Schreder, Martin
    Schirbel, Andreas
    Samnick, Samuel
    Kortuem, Klaus Martin
    Herrmann, Ken
    Kropf, Saskia
    Einsele, Herrmann
    Buck, Andreas K.
    Wester, Hans-Juergen
    Knop, Stefan
    Lueckerath, Katharina
    [J]. THERANOSTICS, 2017, 7 (01): : 205 - 212
  • [6] D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy
    Luyten, Kaat
    Van Loy, Tom
    Cawthorne, Christopher
    Deroose, Christophe M.
    Schols, Dominique
    Bormans, Guy
    Cleeren, Frederik
    [J]. PHARMACEUTICS, 2021, 13 (10)
  • [7] Chemokine receptor-4 targeted PET/CT with 68Ga-Pentixafor in assessment of newly diagnosed multiple myeloma: comparison to 18F-FDG PET/CT
    Pan, Qingqing
    Cao, Xinxin
    Luo, Yaping
    Li, Jian
    Feng, Jun
    Li, Fan
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (03) : 537 - 546
  • [8] [177Lu]pentixather: Comprehensive Preclinical Characterization of a First CXCR4-directed Endoradiotherapeutic Agent
    Schottelius, Margret
    Osl, Theresa
    Poschenrieder, Andreas
    Hoffmann, Frauke
    Beykan, Seval
    Haenscheid, Heribert
    Schirbel, Andreas
    Buck, Andreas K.
    Kropf, Saskia
    Schwaiger, Markus
    Keller, Ulrich
    Lassmann, Michael
    Wester, Hans-Juergen
    [J]. THERANOSTICS, 2017, 7 (09): : 2350 - 2362
1