The impact of assisted reproductive technologies on ADHD: A systematic review and meta-analysis

被引：0
作者：
Hwang, Seongbeen [1 ]
Jung, Jinyoung [1 ]
Moon, Hyunoh [1 ]
Ko, Dai Sik [2 ]
Kim, Hyun-Woo [3 ]
Yoon, Jung-Pil [4 ]
Kim, Won Kyu [5 ,6 ,7 ]
Seol, Aeran [8 ,9 ]
Kim, Kihun [10 ,11 ]
Kim, Yun Hak [10 ,11 ]
机构：
[1] Pusan Natl Univ, Sch Med, Yangsan 50612, South Korea
[2] Gachon Univ, Gil Med Ctr, Dept Gen Surg, Div Vasc Surg,Coll Med, Incheon 21556, South Korea
[3] Pusan Natl Univ, Yangsan Hosp, Dept Neurol, Yangsan 50612, South Korea
[4] Pusan Natl Univ, Yangsan Hosp, Dept Anesthesia & Pain Med, Yangsan 50612, South Korea
[5] Korea Inst Sci & Technol KIST, Nat Prod Res Ctr, Kangnung 25451, South Korea
[6] Univ Sci & Technol UST, Div Nat Prod Appl Sci, Seoul 34113, South Korea
[7] Yonsei Univ, Wonju Coll Med, Dept Convergence Med, Wonju 26426, South Korea
[8] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 03080, South Korea
[9] Korea Univ, Ansan Hosp, Dept Obstet & Gynecol, Ansan 02841, South Korea
[10] Pusan Natl Univ, Sch Med, Dept Biomed Informat, 49 Busandaehak Ro, Yangsan 50612, South Korea
[11] Pusan Natl Univ, Sch Med, Dept Anat, 49 Busandaehak Ro, Yangsan 50612, South Korea
来源：
ASIAN JOURNAL OF PSYCHIATRY | 2024年 / 99卷
基金：
新加坡国家研究基金会;
关键词：
in vitro fertilization; intra-cytoplasmic sperm injection; assisted reproductive technology; attention-deficit/hyperactivity disorder; systematic review; meta-analysis; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CHILDREN BORN; IN-VITRO; NORDIC REGISTER; BIRTH; WEIGHT; COHORT; RISK;
D O I：
10.1016/j.ajp.2024.104125
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: The escalating utilization of assisted reproductive technology (ART) in response to global infertility rates has spurred research into its complications. Short-term and long-term outcomes have been extensively studied, particularly the neurological concerns surrounding attention-deficit/hyperactivity disorder (ADHD) among ART-conceived children. This study aims investigate the association between ART and ADHD. Methods: Medline, Embase, Scopus, and Web of Science databases were searched through April 4, 2023. Cohort, case-control, and cross-sectional studies were eligible for inclusion. primary summary measures included the unadjusted relative risk (RR) and adjusted hazard ratio (HR) with 95 % confidence intervals. Both fixed-effects and random-effects models were utilized for meta-analysis data pooling to determine the overall effect size. The onset of ADHD in children conceived through ART compared to those conceived naturally. Results: The systematic search yielded 8 studies with 10,176,148 individuals included in the meta-analysis. The meta-analysis revealed a pooled RR of 0.93 (0.68-1.26) for cohort studies and a pooled RR of 0.97 (0.41-2.29) for cross-sectional studies, along with a pooled HR of 1.08 (1.03-1.13) for ADHD in the ART group compared to the non-ART group. Conclusion: While this study identifies some potential association between ART and ADHD, the limited effect size and inherent heterogeneity underscore the need for cautious interpretation.
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页数：6
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