Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution

被引：2

作者：

He, Bin ^{[3
]}

Chen, Gen-Qiang ^{[4
,5
]}

Zhang, Xumu ^{[1
,2
,6
]}

机构：

[1] Southern Univ Sci & Technol, Med X Pingshan, Shenzhen 518000, Peoples R China

[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China

[3] Inst Zhejiang Univ Quzhou, Quzhou 324000, Peoples R China

[4] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

[5] Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China

[6] Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 72期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; HALOGENATED KETONES; AROMATIC KETONES; RUTHENIUM; COMPLEXES; RHODIUM; LIGAND;

D O I：

10.1039/d4cc02529f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel synthetic route was developed for the construction of chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding alpha-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 : 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000).

引用

页码：9785 / 9788

页数：4

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