Vaccinations in patients with chronic lymphocytic leukemia

被引：2

作者：

Francis, Elizabeth R. ^{[1
]}

Vu, Jennifer ^{[2
]}

Perez, Catherine Ostos ^{[1
]}

Sun, Clare ^{[3
]}

机构：

[1] NCI, NIH, Bethesda, MD USA

[2] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Chicago, IL 60064 USA

[3] NHLBI, NIH, Bldg 10-CRC,Room 3-5132,10 Ctr Dr, Bethesda, MD 20892 USA

来源：

SEMINARS IN HEMATOLOGY | 2024年 / 61卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Chronic lymphocytic leukemia; CLL; COVID-19; Influenza; Pneumococcal; Hepatitis B; Herpes zoster; TDaP; Vaccine; Immune dysfunction; KILLER-CELL-ACTIVITY; IMMUNE-RESPONSE; T-CELLS; SERUM IMMUNOGLOBULINS; COVID-19; VACCINATION; INFLUENZA VACCINE; NATURAL-HISTORY; INFECTION; CLL; NK;

D O I：

10.1053/j.seminhematol.2024.01.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic lymphocytic leukemia (CLL) is characterized by immune dysfunction resulting in heightened susceptibility to infections and elevated rates of morbidity and mortality. A key strategy to mitigate infection -related complications has been immunization against common pathogens. However, the immunocompromised status of CLL patients poses challenges in eliciting an adequate humoral and cellular immune response to vaccination. Most CLL-directed therapy disproportionately impairs humoral immunity. Vaccine responsiveness also depends on the phase and type of immune response triggered by immunization. In this review, we discuss the immune dysfunction, vaccine responsiveness, and considerations for optimizing vaccine response in patients with CLL. Published by Elsevier Inc.

引用

页码：131 / 138

页数：8

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