Nanotechnology for tau pathology in Alzheimer's disease

被引：3

作者：

Ma, Rongrong ^{[1
]}

Mu, Qianwen ^{[1
,2
]}

Xi, Yue ^{[1
]}

Liu, Gang ^{[2
]}

Liu, Chao ^{[1
,2
,3
]}

机构：

[1] Xiamen Univ, Sch Pharmaceut Sci, State Key Lab Stress Biol, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Ctr Mol Imaging & Translat Med, Sch Publ Hlth,State Key Lab Mol Vaccinol & Mol Di, Xiamen 361102, Peoples R China

[3] Xiamen Univ, Shenzhen Res Inst, Shenzhen 518000, Peoples R China

来源：

MATERIALS TODAY BIO | 2024年 / 27卷

基金：

中国国家自然科学基金;

关键词：

Nanotechnology; Tau protein; Alzheimer's disease; Tau phosphorylation; PAIRED HELICAL FILAMENTS; PROGRESSIVE SUPRANUCLEAR PALSY; NEUROFIBRILLARY TANGLES; PROTEIN-TAU; THERAPEUTIC TARGET; IN-VITRO; PHOSPHORYLATION; BRAIN; NANOPARTICLES; ISOFORMS;

D O I：

10.1016/j.mtbio.2024.101145

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Tau protein aggregation is a defining characteristic of Alzheimer's disease (AD), leading to the formation of neurofibrillary tangles that disrupt neural communication and ultimately result in cognitive decline. Nanotechnology presents novel strategies for both diagnosing and treating Alzheimer's disease. Nanotechnology. It has become a revolutionary tool in the fight against Alzheimer's disease, particularly in addressing the pathological accumulation of tau protein. This review explores the relationship between tau-related neurophysiology and the utilization of nanotechnology for AD treatment, focusing on the application of nanomaterials to regulate tau phosphorylation, hinder tau aggregation and propagation, stabilize microtubules, eliminate pathological tau and emphasize the potential of nanotechnology in developing personalized therapies and monitoring treatment responses in AD patients. This review combines tau-related neurophysiology with nanotechnology to provide new insights for further understanding and treating Alzheimer's disease.

引用

页数：12

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