The positive role of transforming growth factor- β 1 in ischemic stroke

被引：0
作者：
Li, Zi-Rong [1 ]
Wang, Yong-Yan [1 ]
Wang, Zi-Han [1 ]
Qin, Qi-Lin [1 ]
Huang, Cheng [1 ]
Shi, Guang-Sen [1 ]
He, Hong-Yun [1 ,2 ]
Deng, Yi-Hao [1 ]
He, Xiu-Ying [3 ]
Zhao, Xiao-Ming [1 ,2 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Med, Kunming, Peoples R China
[2] Kunming Univ Sci & Technol, Anning Peoples Hosp 1, Kunming, Peoples R China
[3] Sichuan Univ, West China Hosp, Inst Neurol Dis, Dept Anesthesiol, Chengdu, Peoples R China
来源：
CELLULAR SIGNALLING | 2024年 / 121卷
基金：
中国国家自然科学基金;
关键词：
Ischemic stroke; Autophagic flux; Vascular remodeling; Blood-brain barrier; Neuroinflammation; TGF-beta; 1; BLOOD-BRAIN-BARRIER; TGF-BETA-1/SMAD3 SIGNALING PATHWAY; REPERFUSION INJURY; INFLAMMATION; ANGIOGENESIS; AUTOPHAGY; TISSUE; HEMORRHAGE; MICROGLIA; RATS;
D O I：
10.1016/j.cellsig.2024.111301
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ischemic stroke is one of the most disabling and fatal diseases around the world. The damaged brain tissues will undergo excessive autophagy, vascular endothelial cells injury, blood-brain barrier (BBB) impairment and neuroinflammation after ischemic stroke. However, there is no unified viewpoint on the underlying mechanism of brain damage. Transforming growth factor-beta 1 (TGF-beta 1), as a multi-functional cytokine, plays a crucial role in the intricate pathological processes and helps maintain the physiological homeostasis of brain tissues through various signaling pathways after ischemic stroke. In this review, we summarize the protective role of TGF-beta 1 in autophagic flux, BBB, vascular remodeling, neuroinflammation and other aspects after ischemic stroke. Based on the review, we believe that TGF-beta 1 could serve as a key target for treating ischemic stroke.
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收藏
页数：8
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