Natural L-type calcium channels antagonists from Chinese medicine

被引：0

作者：

Xu, Fangfang ^{[1
]}

Cai, Wanna ^{[1
]}

Liu, Bo ^{[1
]}

Qiu, Zhenwen ^{[2
]}

Zhang, Xiaoqi ^{[3
]}

机构：

[1] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510006, Peoples R China

[2] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China

[3] Jinan Univ, Guangdong Prov Engn Res Ctr Modernizat TCM, NMPA Key Lab Qual Evaluat TCM, Guangzhou 510632, Peoples R China

来源：

CHINESE MEDICINE | 2024年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

LTCCs; Antagonists; Excitation-contraction coupling; TCM; Natural phytochemicals; SALVIANOLIC ACID-B; CA2+ CHANNELS; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; CONTRACTILITY; INVOLVEMENT; DISORDER; ARTERY; COMPONENT; QUERCETIN;

D O I：

10.1186/s13020-024-00944-8

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca2+-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological and psychological diseases for decades. Natural products from Traditional Chinese medicine (TCM) have shown the potential as new drugs for the treatment of LTCCs related diseases. In this review, the basic structure, function of LTCCs, and the related human diseases caused by structural or functional abnormalities of LTCCs, and the natural LTCCs antagonist and their potential usages were summarized.

引用

页数：22

共 116 条

[71] The β2-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy [J].

Pickel, Simone ;

Cruz-Garcia, Yiliam ;

Bandleon, Sandra ;

Barkovits, Katalin ;

Heindl, Cornelia ;

Voelker, Katharina ;

Abesser, Marco ;

Pfeiffer, Kathy ;

Schaaf, Alice ;

Marcus, Katrin ;

Eder-Negrin, Petra ;

Kuhn, Michaela ;

Miranda-Laferte, Erick .

FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8

[72] Temperature-Sensitive Cav1.2 Calcium Channels Support Intrinsic Firing of Pyramidal Neurons and Provide a Target for the Treatment of Febrile Seizures [J].

Radzicki, Daniel ;

Yau, Hau-Jie ;

Pollema-Mays, Sarah L. ;

Mlsna, Lauren ;

Cho, Kangho ;

Koh, Sookyong ;

Martina, Marco .

JOURNAL OF NEUROSCIENCE, 2013, 33 (24) :9920-9931

[73] The effect of ligustrazine on L-type calcium current, calcium transient and contractility in rabbit ventricular myocytes [J].

Ren, Zhiqiang ;

Ma, Jihua ;

Zhang, Peihua ;

Luo, Antao ;

Zhang, Shuo ;

Kong, Linghao ;

Qian, Chunping .

JOURNAL OF ETHNOPHARMACOLOGY, 2012, 144 (03) :555-561

[74] The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels [J].

Saponara, S. ;

Carosati, E. ;

Mugnai, P. ;

Sgaragli, G. ;

Fusi, F. .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 164 (06) :1684-1697

[75] Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells [J].

Saponara, S ;

Sgaragli, G ;

Fusi, F .

BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (07) :1819-1827

[76] Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca2+ channels [J].

Saponara, Simona ;

Sgaragli, Giampietro ;

Fusi, Fabio .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 598 (1-3) :75-80

[77] Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies [J].

Sengul, Mustafa ;

Karadas, Baris ;

Acar-Sahan, Selin ;

Simsek, Fatma ;

Horoz, Ersan ;

Ozok, Isik Cem ;

Temiz, Tijen .

FETAL AND PEDIATRIC PATHOLOGY, 2023, 42 (06) :845-859

[78]

Serebruany VL, 1998, AM J HEMATOL, V57, P309, DOI 10.1002/(SICI)1096-8652(199804)57:4<309::AID-AJH7>3.0.CO

[79]

2-Y

[80] Neuronal Voltage-Gated Calcium Channels: Structure, Function, and Dysfunction [J].

Simms, Brett A. ;

Zamponi, Gerald W. .

NEURON, 2014, 82 (01) :24-45

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