Natural L-type calcium channels antagonists from Chinese medicine

被引：0
作者：
Xu, Fangfang [1 ]
Cai, Wanna [1 ]
Liu, Bo [1 ]
Qiu, Zhenwen [2 ]
Zhang, Xiaoqi [3 ]
机构：
[1] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510006, Peoples R China
[2] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Peoples R China
[3] Jinan Univ, Guangdong Prov Engn Res Ctr Modernizat TCM, NMPA Key Lab Qual Evaluat TCM, Guangzhou 510632, Peoples R China
来源：
CHINESE MEDICINE | 2024年 / 19卷 / 01期
基金：
中国国家自然科学基金;
关键词：
LTCCs; Antagonists; Excitation-contraction coupling; TCM; Natural phytochemicals; SALVIANOLIC ACID-B; CA2+ CHANNELS; MYOCARDIAL-ISCHEMIA; OXIDATIVE STRESS; CONTRACTILITY; INVOLVEMENT; DISORDER; ARTERY; COMPONENT; QUERCETIN;
D O I：
10.1186/s13020-024-00944-8
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca2+-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological and psychological diseases for decades. Natural products from Traditional Chinese medicine (TCM) have shown the potential as new drugs for the treatment of LTCCs related diseases. In this review, the basic structure, function of LTCCs, and the related human diseases caused by structural or functional abnormalities of LTCCs, and the natural LTCCs antagonist and their potential usages were summarized.
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