Long-Term Follow-Up of a Case of Probable Aspergillus Skull Base Osteomyelitis With Galactomannan Test and Literature Review

被引：0

作者：

Cao, Xihong ^{[1
]}

Wang, Yating ^{[2
]}

Zhang, Qingyu ^{[3
]}

Chen, Lijuan ^{[2
]}

Zhu, Zhengwen ^{[2
]}

Yu, Zhenkun ^{[2
]}

Jie, Huang ^{[2
]}

机构：

[1] Sci City Hosp Sichuan Prov, Dept Pharm, Mianyang, Sichuan, Peoples R China

[2] Nanjing Med Univ, BenQ Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Affiliated BenQ Hosp, 71 Hexi St, Nanjing 210019, Jiangsu, Peoples R China

[3] Nanjing Med Univ, BenQ Med Ctr, Radiol Dept, Affiliated BenQ Hosp, Nanjing, Jiangsu, Peoples R China

来源：

ENT-EAR NOSE & THROAT JOURNAL | 2024年

关键词：

invasive fungal disease; aspergillus; osteomyelitis; galactomannan test; voriconazole; NERVOUS-SYSTEM ASPERGILLOSIS; MALIGNANT OTITIS-EXTERNA; INVASIVE ASPERGILLUS; FUNGAL OSTEOMYELITIS; MASTOIDITIS; INFECTIONS; DIAGNOSIS;

D O I：

10.1177/01455613241235561

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

We report a probable case of Aspergillus basicranial infection diagnosed by pathogenic serological examination presenting atypical initial manifestations, and highlight the importance of serological examination to avoid treatment delay and disease management. An 84-year-old diabetic patient presented with right peripheral nerve palsy, intolerable otalgia, hearing loss, dysphagia, hoarseness, and bucking. The patient was diagnosed a probable Aspergillus skull base osteomyelitis with cranial neuritis and meningitis of central nervous system. Galactomannan test was used in combination with 1-3-beta-D-glucan and magnetic resonance imaging to follow-up during the continuous treatment of voriconazole. To date, the patient has remained in clinical remission for over 39 months but the drug cannot be stopped safely.

引用

页数：6

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