Mechanisms of Postischemic Stroke Angiogenesis: A Multifaceted Approach

被引：6

作者：

Hu, Bin ^{[1
]}

Pei, Jingchun ^{[1
]}

Wan, Cheng ^{[1
,2
]}

Liu, Shuangshuang ^{[1
]}

Xu, Zhe ^{[3
,4
]}

Zou, Yongwei ^{[1
]}

Li, Zhigao ^{[1
]}

Tang, Zhiwei ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 1, Dept Neurosurg, 295 Xichang Rd, Kunming 650032, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 1, Dept Med Imaging, Kunming, Peoples R China

[3] Kunming Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Kunming, Peoples R China

[4] Qujing Med Coll, Sch Basic Med Sci, Qujing, Peoples R China

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2024年 / 17卷

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; angiogenesis; signaling pathways; BLOOD-BRAIN-BARRIER; GROWTH-FACTOR-I; ACUTE ISCHEMIC-STROKE; NF-KAPPA-B; MICROVASCULAR ENDOTHELIAL-CELLS; HUMAN URINARY KALLIDINOGENASE; COLONY-STIMULATING FACTOR; FOCAL CEREBRAL-ISCHEMIA; SMOOTH-MUSCLE-CELLS; PROMOTES ANGIOGENESIS;

D O I：

10.2147/JIR.S461427

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ischemic stroke constitutes a significant global health care challenge, and a comprehensive understanding of its recovery mechanisms is imperative for the development of innovative therapeutic strategies. Angiogenesis, a pivotal element of ischemic tissue repair, facilitates the restoration of blood flow to damaged regions, thereby promoting neuronal regeneration and functional recovery. Nevertheless, the mechanisms underlying postischemic stroke angiogenesis remain incompletely elucidated. This review meticulously examines the constituents of the neurovascular unit, ion channels, molecular mediators, and signaling pathways implicated in angiogenesis following stroke. Furthermore, it delves into prospective therapeutic strategies informed by these factors. Our objective is to provide detailed and exhaustive information on the intricate mechanisms governing postischemic stroke angiogenesis, thus providing a robust scientific foundation for the advancement of novel neurorepair therapies.

引用

页码：4625 / 4646

页数：22

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