The Th1/Th2 paradigm: A misrepresentation of helper T cell plasticity

被引：6

作者：

Rogozynski, Noah P. ^{[1
]}

Dixon, Brian ^{[1
]}

机构：

[1] Univ Waterloo, Dept Biol, Waterloo, ON, Canada

来源：

IMMUNOLOGY LETTERS | 2024年 / 268卷

关键词：

Helper T cell; Plasticity; Th1/Th2; paradigm; Hybrid Th cell; Autoimmunity; Th subsets; TH1; EFFECTOR; SUBSETS; CYTOKINES; BALANCE;

D O I：

10.1016/j.imlet.2024.106870

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

For decades, the Th1/2 paradigm has been used to classify immune responses as either Th1 or Th2-biased. However, in recent years, a staggering amount of evidence has emerged to support rejection of the classical Th1/Th2 paradigm, such as the discoveries of new helper T cell subsets, helper T cell plasticity and protective mixed-Th1/Th2 responses. This opinion piece investigates the shortcomings of classical Th1/Th2 paradigm in the context of recent works, with the goal of facilitating the development of newer models to represent the diversity of Th cells.

引用

页数：5

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