Genetics and Epigenetics in the Genesis and Development of Microtia

被引：1

作者：

Chen, Xin ^{[1
]}

Ma, Jing ^{[1
,3
]}

Zhang, Tianyu ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Eye & ENT Hosp, ENT Inst, Dept Facial Plast & Reconstruct Surg, Shanghai, Peoples R China

[2] Fudan Univ, NHC Key Lab Hearing Med, Shanghai, Peoples R China

[3] 83 Fenyang Rd, Shanghai, Peoples R China

来源：

JOURNAL OF CRANIOFACIAL SURGERY | 2024年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Ear development; epigenetics; genetics; microtia; syndrome; TRANSCRIPTION FACTOR; CONGENITAL MICROTIA; MUTATIONS; EAR; EXPRESSION; HOXA2; MODEL; SIX1; MICE; PROLIFERATION;

D O I：

10.1097/SCS.0000000000010004

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Microtia is a congenital malformation of the external and middle ear associated with varying degrees of severity that range from mild structural abnormalities to the absence of the external ear and auditory canal. Globally, it is the second most common congenital craniofacial malformation and is typically caused by inherited defects, external factors, or the interaction between genes and external factors. Epigenetics notably represents a bridge between genetics and the environment. This review has devoted attention to the current proceedings of the genetics and epigenetics of microtia and related syndromes.

引用

页码：e261 / e266

页数：6

共 67 条

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