circRNAs in Endometrial Cancer-A Promising Biomarker: State of the Art

被引：3

作者：

Wlodarczyk, Karolina ^{[1
]}

Kurylo, Weronika ^{[1
]}

Pawlowska-Lachut, Anna ^{[1
]}

Skiba, Wiktoria ^{[1
]}

Suszczyk, Dorota ^{[1
]}

Pieniadz, Paulina ^{[1
,2
]}

Majewska, Malgorzata ^{[3
]}

Boniewska-Bernacka, Ewa ^{[4
]}

Wertel, Iwona ^{[1
]}

机构：

[1] Med Univ Lublin, Fac Med, Dept Oncol Gynaecol & Gynaecol, Independent Lab Canc Diagnost & Immunol, Chodzki 1, PL-20093 Lublin, Poland

[2] Marie Curie Sklodowska Univ, Inst Biol & Biotechnol, Dept Virol & Immunol, Akad 19, PL-20031 Lublin, Poland

[3] Marie Curie Sklodowska Univ, Inst Biol & Biotechnol, Dept Ind & Environm Microbiol, Akad 19, PL-20031 Lublin, Poland

[4] Univ Opole, Inst Med Sci, Med Dept, Oleska 48, PL-45052 Opole, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 12期

关键词：

circRNA; biogenesis of circRNAs; function of circRNAs; endometrial cancer; biomarker; CIRCULAR RNA; PROGRESSION; CARCINOMA; MIGRATION; PROMOTES; PROLIFERATION; MECHANISMS; EXPRESSION; RESISTANCE; INVASION;

D O I：

10.3390/ijms25126387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endometrial cancer (EC) is one of the most common malignant tumors among women in the 21st century, whose mortality rate is increasing every year. Currently, the diagnosis of EC is possible only after a biopsy. However, it is necessary to find a new biomarker that will help in both the diagnosis and treatment of EC in a non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical and stable long non-coding RNAs (lncRNAs) molecules, which are abundant in both body fluids and human tissues and are expressed in various ways. Considering the new molecular classification of EC, many studies have appeared, describing new insights into the functions and mechanisms of circRNAs in EC. In this review article, we focused on the problem of EC and the molecular aspects of its division, as well as the biogenesis, functions, and diagnostic and clinical significance of circRNAs in EC.

引用

页数：20

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