Deciphering the Plasmodium falciparum perinuclear var gene expression site

被引:0
作者
Diffendall, Gretchen [1 ]
Scherf, Artur [1 ]
机构
[1] Univ Paris Cite, Inst Pasteur, INSERM, CNRS,EMR 9195,U1201, Paris, France
关键词
MUTUALLY EXCLUSIVE EXPRESSION; ANTIGENIC VARIATION; VIRULENCE GENES; PROMOTERS; GENOME; REVEALS; REGIONS; RNA;
D O I
10.1016/j.pt.2024.06.002
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The protozoan parasite Plasmodium falciparum, responsible for the deadliest form of human malaria, employs antigenic variation via monoallelic expression as a key survival strategy. The selective activation of one out of the 60-member var gene family is key to understanding the parasite's ability to cause severe disease and evade the host immune response. var gene activation is initiated by its relocation to a specialized expression site. While the perinuclear expression site (PES) plays a crucial role in enabling the expression of a single allele, the characteristics of this PES remain largely obscure. Recent breakthroughs in genome editing tools and the discovery of regulatory noncoding RNAs have shed light on this intriguing biological feature, offering significant insights into the mechanisms of pathogen virulence.
引用
收藏
页码:707 / 716
页数:10
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