Dopamine Release Dynamics in the Nucleus Accumbens Are Modulated by the Timing of Electrical Stimulation Pulses When Applied to the Medial Forebrain Bundle and Medial Prefrontal Cortex

被引:0
作者
Hamilton, Andrea R. [1 ]
Vishwanath, Abhilasha [2 ]
Weintraub, Nathan C. [1 ]
Cowen, Stephen L. [2 ,3 ]
Heien, M. Leandro [1 ]
机构
[1] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
[3] Univ Arizona, Evelyn F McKnight Brain Inst, Tucson, AZ 85721 USA
来源
ACS CHEMICAL NEUROSCIENCE | 2024年 / 15卷 / 14期
关键词
dopamine; electrical stimulation; fast-scancyclic voltammetry; nucleus accumbens; local variance; interpulse interval; DEEP BRAIN-STIMULATION; HIGH-FREQUENCY STIMULATION; VENTRAL TEGMENTAL AREA; SUBTHALAMIC NUCLEUS; SELF-STIMULATION; RAT; TRANSMISSION; PROJECTIONS; GLUTAMATE; NEURONS;
D O I
10.1021/acschemneuro.4c00115
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Electrical brain stimulation has been used in vivo and in vitro to investigate neural circuitry. Historically, stimulation parameters such as amplitude, frequency, and pulse width were varied to investigate their effects on neurotransmitter release and behavior. These experiments have traditionally employed fixed-frequency stimulation patterns, but it has previously been found that neurons are more precisely tuned to variable input. Introducing variability into the interpulse interval of stimulation pulses will inform on how dopaminergic release can be modulated by variability in pulse timing. Here, dopaminergic release in rats is monitored in the nucleus accumbens (NAc), a key dopaminergic center which plays a role in learning and motivation, by fast-scan cyclic voltammetry. Dopaminergic release in the NAc could also be modulated by stimulation region due to differences in connectivity. We targeted two regions for stimulation-the medial forebrain bundle (MFB) and the medial prefrontal cortex (mPFC)-due to their involvement in reward processing and projections to the NAc. Our goal is to investigate how variable interpulse interval stimulation patterns delivered to these regions affect the time course of dopamine release in the NAc. We found that stimulating the MFB with these variable stimulation patterns saw a highly responsive, frequency-driven dopaminergic response. In contrast, variable stimulation patterns applied to the mPFC were not as sensitive to the variable frequency changes. This work will help inform on how stimulation patterns can be tuned specifically to the stimulation region to improve the efficiency of electrical stimulation and control dopamine release.
引用
收藏
页码:2643 / 2653
页数:11
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