The Role of Neuro-Immune Interactions in the Pathology and Pathogenesis of Allergic Rhinitis

被引：0
作者：
Lan, Ya-An [1 ]
Guo, Jia-Xi [1 ]
Yao, Min-Hua [1 ]
Kang, Yi-Ting [1 ]
Liao, Zi-Rui [1 ]
Jing, Yu-Hong [1 ,2 ]
机构：
[1] Lanzhou Univ, Inst Anat & Histol & Embryol, Sch Basic Med Sci, Neurosci, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou, Gansu, Peoples R China
来源：
IMMUNOLOGICAL INVESTIGATIONS | 2024年 / 53卷 / 07期
关键词：
Allergic rhinitis; neuro-immune cell units (NICUs); neuron-immue interactions; SUBSTANCE-P; MAST-CELLS; NITRIC-OXIDE; CHRONIC INFLAMMATION; NERVOUS-SYSTEM; EXPRESSION; ACTIVATION; RECEPTOR; ORIGIN; IMPACT;
D O I：
10.1080/08820139.2024.2382792
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
BackgroundAllergic rhinitis (AR) is a non-infectious inflammatory disease of the nasal mucosa mediated by IgE and involving a variety of immune cells such as mast cells. In previous studies, AR was considered as an isolated disease of the immune system. However, recent studies have found that the nervous system is closely related to the development of AR. Bidirectional communication between the nervous and immune systems plays an important role in AR.SummaryThe nervous system and immune system depend on the anatomical relationship between nerve fibers and immune cells, as well as various neurotransmitters, cytokines, inflammatory mediators, etc. to produce bidirectional connections, which affect the development of AR.Key messagesThis article reviews the impact of neuro-immune interactions in AR on the development of AR, including neuro-immune cell units.
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页码：1013 / 1029
页数：17
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