Photodynamic Anticancer and Antibacterial Activities of Sn(IV) N-Confused Meso-tetra(methylthiophenyl)porphyrin

被引:8
作者
Dingiswayo, Somila [1 ]
Babu, Balaji [1 ,2 ]
Burgess, Kristen [1 ]
Mack, John [1 ]
Nyokong, Tebello [1 ]
机构
[1] Rhodes Univ, Inst Nanotechnol Innovat, ZA-6140 Makhanda, South Africa
[2] SRM Univ AP, Dept Chem, Amaravati 522502, India
来源
PHOTOCHEM | 2023年 / 3卷 / 03期
基金
新加坡国家研究基金会;
关键词
N-confused porphyrins; photophysics; singlet oxygen; photodynamic therapy; photodynamic antimicrobial chemotherapy; TD-DFT calculations; PORPHYRINS; THERAPY; PHOTOSENSITIZERS; PHTHALOCYANINES; ISOMER;
D O I
10.3390/photochem3030019
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
A Sn(IV) meso-tetra(4-methylthiolphenyl) N-confused porphyrin (4-Sn) complex was prepared to facilitate a comparison of the photophysicochemical and singlet oxygen photosensitiser properties of a series of Sn(IV) complexes of meso-4-methylthiolphenyl-substituted porphyrin, corrole, chlorin, and N-confused porphyrin. 4-Sn has an unusually high singlet oxygen quantum (Phi(Delta)) yield of 0.88, markedly higher than the Phi(Delta) values of the other complexes in this series. A Thorlabs M660L4 LED (280 mW <middle dot> cm(-2)) was used to study the photodynamic activity of Sn-4 against the MCF-7 cancer cell line through irradiation at 660 nm for 30 min. The IC50 value was calculated to be 1.4 (+/- 0.8) mu M, markedly lower than the previously reported values for the rest of the series. Photodynamic antimicrobial activity was also determined against Staphylococcus aureus and Escherichia coli, and 4-Sn was found to deactivate both Gram-(+) and Gram-(-) bacteria despite the absence of cationic charges on the ligand structure.
引用
收藏
页码:313 / 326
页数:14
相关论文
共 47 条
[1]   Oncologic photodynamic therapy photosensitizers: A clinical review [J].
Allison, Ron R. ;
Sibata, Claudio H. .
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75
[2]  
[Anonymous], 2004, DRUGS R&D, V5, P58, DOI [10.2165/00126839-200405010-00013, DOI 10.2165/00126839-200405010-00013]
[3]   Sn(IV)-porphyrinoids for photodynamic anticancer and antimicrobial chemotherapy [J].
Babu, Balaji ;
Mack, John ;
Nyokong, Tebello .
DALTON TRANSACTIONS, 2023, 52 (16) :5000-5018
[4]   A heavy-atom-free π-extended N-confused porphyrin as a photosensitizer for photodynamic therapy [J].
Babu, Balaji ;
Mack, John ;
Nyokong, Tebello .
NEW JOURNAL OF CHEMISTRY, 2021, 45 (12) :5654-5658
[5]   Photodynamic activity of Sn(IV) tetrathien-2-ylchlorin against MCF-7 breast cancer cells [J].
Babu, Balaji ;
Mack, John ;
Nyokong, Tebello .
DALTON TRANSACTIONS, 2021, 50 (06) :2177-2182
[6]   Thien-2-yl substituted chlorins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy [J].
Babu, Balaji ;
Sindelo, Azole ;
Mack, John ;
Nyokong, Tebello .
DYES AND PIGMENTS, 2021, 185 (185)
[7]   Sn(iv) N-confused porphyrins as photosensitizer dyes for photodynamic therapy in the near IR region [J].
Babu, Balaji ;
Mack, John ;
Nyokong, Tebello .
DALTON TRANSACTIONS, 2020, 49 (43) :15180-15183
[8]   An octabrominated Sn(IV) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications [J].
Babu, Balaji ;
Mack, John ;
Nyokong, Tebello .
DALTON TRANSACTIONS, 2020, 49 (28) :9568-9573
[9]   Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy [J].
Babu, Balaji ;
Soy, Rodah C. ;
Mack, John ;
Nyokong, Tebello .
NEW JOURNAL OF CHEMISTRY, 2020, 44 (26) :11006-11012
[10]   Synthesis, characterization and photodynamic activity of Sn(IV) triarylcorroles with red-shifted Q bands [J].
Babu, Balaji ;
Prinsloo, Earl ;
Mack, John ;
Nyokong, Tebello .
NEW JOURNAL OF CHEMISTRY, 2019, 43 (47) :18805-18812