Advances in the treatment of type 2 diabetes mellitus by natural plant polysaccharides through regulation of gut microbiota and metabolism: A review

被引：13

作者：

Chuanboding ^{[1
,4
]}

Wang, Ning ^{[3
]}

He, Huiying ^{[3
]}

Sun, Xiaohang ^{[2
]}

Bi, Xiaoyu ^{[2
]}

Li, Anning ^{[4
]}

Sun, Pingping ^{[4
]}

Li, Jianguo ^{[4
]}

Yan, Li ^{[4
]}

Gao, Yang ^{[5
]}

Shen, Liqian ^{[5
]}

Ting, Zhao ^{[1
]}

Zhang, Shuai ^{[1
,2
]}

机构：

[1] Jilin Agr Sci & Technol Coll, Coll Tradit Chinese Med, Jilin 132101, Peoples R China

[2] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[3] Jilin Agr Univ, Coll Resources & Environm, Changchun 130118, Peoples R China

[4] Jilin Aodong Yanbian Pharmaceut Co Ltd, Yanbian Korean Autonomous 133000, Peoples R China

[5] Jilin Jianwei Nat Biotechnol Co Ltd, Baishan 134600, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 274卷

关键词：

Natural plant polysaccharides; Type 2 diabetes mellitus; Constitutive relationship; Gut microbiota; GLUCOSIDASE INHIBITORY-ACTIVITY; VITRO HYPOGLYCEMIC ACTIVITIES; HIGH-FAT-DIET; IN-VITRO; ALPHA-GLUCOSIDASE; GANODERMA-LUCIDUM; STRUCTURAL-CHARACTERIZATION; PHYSICOCHEMICAL PROPERTIES; MUSHROOM POLYSACCHARIDES; BILE-ACID;

D O I：

10.1016/j.ijbiomac.2024.133466

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prevalence and impact of type 2 diabetes mellitus (T2DM) is a major global health problem. The treatment process of T2DM is long and difficult to cure. Therefore, it is necessary to explore alternative or complementary methods to deal with the various challenges brought by T2DM. Natural plant polysaccharides (NPPs) have certain potential in the treatment of T2DM. However, many studies have not considered the relationship between the structure of NPPs and their anti-T2DM activity. This paper reviews the relevant anti-T2DM mechanisms of NPPs, including modulation of insulin action, promotion of glucose metabolism and modulation of postprandial glucose levels, anti-inflammation and modulation of gut microbiota (GM) and metabolism. This paper provides an in-depth study of the conformational relationships of NPPs and facilitates the development of anti-T2DM drugs or dietary supplements with NPPs.

引用

页数：13

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