Research progress of cGAS-STING signaling pathway in intestinal diseases

被引：2
|
作者：
Wang, Jiamin [1 ]
Yao, Naiqi [2 ]
Chen, Yonghu [1 ]
Li, Xuezheng [1 ,2 ]
Jiang, Zhe [1 ,2 ]
机构：
[1] Minist Educ, Coll Pharm, Key Lab Nat Med Changbai Mt, Yanji 133002, Jilin, Peoples R China
[2] Yanbian Univ Hosp, Dept Pharm, Yanji 133000, Jilin, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 135卷
关键词：
cGAS-STING; Inflammatory bowel disease; Colorectal cancer; Intestinal ischemia/reperfusion; Gut microbiota; NF-KAPPA-B; INFLAMMATORY-BOWEL-DISEASE; INNATE IMMUNE SENSOR; CYTOSOLIC DNA SENSOR; GMP-AMP SYNTHASE; GUT MICROBIOME; I INTERFERON; COLITIS; VIRUS; IFI16;
D O I：
10.1016/j.intimp.2024.112271
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signal has drawn much consideration due to its sensitivity to DNA in innate immune mechanisms. Activation of the cGAS-STIN signaling pathway induces the production of interferon and inflammatory cytokines, resulting in immune responses, or inflammatory diseases. The intestinal tract is a vital organ for the body's nutrition absorption, recent studies have had various points of view on the job of cGAS-STING pathway in various intestinal sicknesses. Therefore, understanding its role and mechanism in the intestinal environment can help to develop new strategies for the treatment of intestinal diseases. This article examines the mechanism of the cGAS-STING pathway and its function in inflammatory bowel disease, intestinal cancer, and long-injury ischemia-reperfusion, lists the current medications that target it for the treatment of intestinal diseases, and discusses the impact of intestinal flora on this signaling pathway, to offer a theoretical and scientific foundation for upcoming targeted therapies for intestinal disorders via the cGAS-STING pathway.
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页数：11
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