Dysregulation of Host-Pathogen Interactions in Sepsis: Host-Related Factors

被引：3

作者：

Joosten, Sebastiaan C. M. ^{[1
]}

Wiersinga, Willem J. ^{[1
,2
]}

van der Poll, Tom ^{[1
,2
]}

机构：

[1] Amsterdam Univ Med Ctr, Ctr Expt & Mol Med, Amsterdam, Netherlands

[2] Amsterdam Univ Med Ctr, Div Infect Dis, Amsterdam, Netherlands

来源：

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 2024年 / 45卷 / 04期

关键词：

sepsis; review; pathophysiology; immune dysregulation; host response; INNATE IMMUNITY; INTRAVASCULAR COAGULATION; TRAINED IMMUNITY; IMMUNOSUPPRESSION; INHIBITION; ACTIVATION; THROMBOSIS; MORTALITY; MONOCYTES; PLATELETS;

D O I：

10.1055/s-0044-1787554

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Sepsis stands as a prominent contributor to sickness and death on a global scale. The most current consensus definition characterizes sepsis as a life-threatening organ dysfunction stemming from an imbalanced host response to infection. This definition does not capture the intricate array of immune processes at play in sepsis, marked by simultaneous states of heightened inflammation and immune suppression. This overview delves into the immune-related processes of sepsis, elaborating about mechanisms involved in hyperinflammation and immune suppression. Moreover, we discuss stratification of patients with sepsis based on their immune profiles and how this could impact future sepsis management.

引用

页码：469 / 478

页数：10

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