Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research

被引:3
作者
Vassal, Mariana [1 ]
Martins, Filipa [1 ]
Monteiro, Bruno [1 ]
Tambaro, Simone [2 ]
Martinez-Murillo, Ricardo [3 ]
Rebelo, Sandra [1 ]
机构
[1] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Aveiro, Portugal
[2] Karolinska Inst, Div Neurogeriatr, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden
[3] CSIC, Dept Translat Neurobiol, Neurovasc Res Grp, Cajal Inst, Madrid, Spain
关键词
Adult neurogenesis; Neurodegenerative diseases; Neural stem cells; Therapeutics; Pre-clinical studies; Clinical research; NEURAL STEM-CELLS; TRANSCRANIAL MAGNETIC STIMULATION; ADULT HIPPOCAMPAL NEUROGENESIS; DEEP BRAIN-STIMULATION; NERVE GROWTH-FACTOR; IMPROVES SPATIAL MEMORY; NEWLY GENERATED NEURONS; ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; ENVIRONMENTAL ENRICHMENT;
D O I
10.1007/s12035-024-04246-w
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neuroscience community has largely accepted the notion that functional neurons can be generated from neural stem cells in the adult brain, especially in two brain regions: the subventricular zone of the lateral ventricles and the subgranular zone in the dentate gyrus of the hippocampus. However, impaired neurogenesis has been observed in some neurodegenerative diseases, particularly in Alzheimer's, Parkinson's, and Huntington's diseases, and also in Lewy Body dementia. Therefore, restoration of neurogenic function in neurodegenerative diseases emerges as a potential therapeutic strategy to counteract, or at least delay, disease progression. Considering this, the present study summarizes the different neuronal niches, provides a collection of the therapeutic potential of different pro-neurogenic strategies in pre-clinical and clinical research, providing details about their possible modes of action, to guide future research and clinical practice.
引用
收藏
页码:46 / 76
页数:31
相关论文
共 373 条
[1]   Adult neurogenesis in the mammalian dentate gyrus [J].
Abbott, Louise C. ;
Nigussie, Fikru .
ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2020, 49 (01) :3-16
[2]   REGULATION AND FUNCTION OF ADULT NEUROGENESIS: FROM GENES TO COGNITION [J].
Aimone, James B. ;
Li, Yan ;
Lee, Star W. ;
Clemenson, Gregory D. ;
Deng, Wei ;
Gage, Fred H. .
PHYSIOLOGICAL REVIEWS, 2014, 94 (04) :991-1026
[3]   Adult Neurogenesis under Control of the Circadian System [J].
Ali, Amira A. H. ;
von Gall, Charlotte .
CELLS, 2022, 11 (05)
[4]   AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].
ALTMAN, J ;
DAS, GD .
JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&
[5]   For the long run: Maintaining germinal niches in the adult brain [J].
Alvarez-Buylla, A ;
Lim, DA .
NEURON, 2004, 41 (05) :683-686
[6]   Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia [J].
Alzobaidi, Nafaa ;
Quasimi, Huma ;
Emad, Nasr A. ;
Alhalmi, Abdulsalam ;
Naqvi, Maaz .
DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE, 2021, 11 :1-14
[7]   Cell proliferation in the dentate gyrus of rat hippocampus is inhibited by soft diet feeding [J].
Aoki, H ;
Kimoto, K ;
Hori, N ;
Toyoda, M .
GERONTOLOGY, 2005, 51 (06) :369-374
[8]   Why Cortical Neurons Cannot Divide, and Why Do They Usually Die in the Attempt? [J].
Aranda-Anzaldo, Armando ;
Dent, Myrna A. R. .
JOURNAL OF NEUROSCIENCE RESEARCH, 2017, 95 (04) :921-929
[9]   The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone [J].
Arnold, Sebastian J. ;
Huang, Guo-Jen ;
Cheung, Amanda F. P. ;
Era, Takumi ;
Nishikawa, Shin-Ichi ;
Bikoff, Elizabeth K. ;
Molnar, Zoltan ;
Robertson, Elizabeth J. ;
Groszer, Matthias .
GENES & DEVELOPMENT, 2008, 22 (18) :2479-2484
[10]   Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases [J].
Babazadeh, Afshin ;
Vahed, Fereshteh Mohammadi ;
Liu, Qi ;
Siddiqui, Shahida Anusha ;
Kharazmi, Mohammad Saeed ;
Jafari, Seid Mahdi .
ACS OMEGA, 2023, :3667-3683