Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas

被引：37

作者：

Driessen, Juliette P. ^{[1
,5
]}

van Bemmel, Alexander J. M. ^{[1
,5
]}

van Kempen, Pauline M. W. ^{[1
,5
]}

Janssen, Luuk M. ^{[1
]}

Terhaard, Chris H. J. ^{[2
]}

Pameijer, Frank A. ^{[3
]}

Willems, Stefan M. ^{[4
]}

Stegeman, Inge ^{[1
,5
]}

Grolman, Wilko ^{[1
,5
]}

Philippens, Marielle E. P. ^{[2
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Otorhinolaryngol Head & Neck Surg, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Radiotherapy, NL-3584 CX Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Dept Radiol, NL-3584 CX Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands

[5] Rudolf Magnus Inst Neurosci, Utrecht, Netherlands

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷

关键词：

head and neck squamous cell carcinoma (HNSCC); diffusion-weighted MRI; diffusion; apparent diffusion coefficient; human papillomavirus (HPV); OROPHARYNGEAL CANCER; TUMOR-STROMA; HPV; SURVIVAL; METAANALYSIS; PREVALENCE; ALGORITHM; PATTERNS; WORLD;

D O I：

10.1002/hed.24051

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Identification of prognostic patient characteristics in head and neck squamous cell carcinoma (HNSCC) is of great importance. Human papillomavirus (HPV)-positive HNSCCs have favorable response to (chemo) radiotherapy. Apparent diffusion coefficient, derived from diffusion-weighted MRI, has also shown to predict treatment response. The purpose of this study was to evaluate the correlation between HPV status and apparent diffusion coefficient. Methods. Seventy-three patients with histologically proven HNSCC were retrospectively analyzed. Mean pretreatment apparent diffusion coefficient was calculated by delineation of total tumor volume on diffusionweighted MRI. HPV status was analyzed and correlated to apparent diffusion coefficient. Results. Six HNSCCs were HPV-positive. HPV-positive HNSCC showed significantly lower apparent diffusion coefficient compared to HPV-negative. This correlation was independent of other patient characteristics. Conclusion. In HNSCC, positive HPV status correlates with low mean apparent diffusion coefficient. The favorable prognostic value of low pretreatment apparent diffusion coefficient might be partially attributed to patients with a positive HPV status. (C) 2015 Wiley Periodicals, Inc.

引用

页码：E613 / E618

页数：6

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