The broken Alzheimer's disease genome

被引：3

作者：

Roque, Claudio Gouveia ^{[1
,2
]}

Phatnani, Hemali ^{[1
,3
]}

Hengst, Ulrich ^{[2
,4
]}

机构：

[1] New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA

[2] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Vagelos Coll Phys & Surg, New York, NY 10032 USA

[3] Columbia Univ, Ctr Translat & Computat Neuroimmunol, Dept Neurol, New York, NY 10032 USA

[4] Columbia Univ, Vagelos Coll Phys & Surg, Dept Pathol & Cell Biol, New York, NY 10032 USA

来源：

CELL GENOMICS | 2024年 / 4卷 / 05期

关键词：

BRAIN DNA METHYLATION; SINGLE-CELL ATLAS; ENTORHINAL CORTEX; CONNECTIVITY MAP; RISK LOCI; GENE; INDIVIDUALS; MICROGLIA; DEMENTIA; APOE;

D O I：

10.1016/j.xgen.2024.100555

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant challenges to therapeutic and preventative interventions. Despite these difficulties, genomics and related disciplines are allowing fundamental mechanistic insights to emerge with clarity, particularly with the introduction of high-resolution sequencing technologies. After all, the disrupted processes at the interface between DNA and gene expression, which we call the broken AD genome, offer detailed quantitative evidence unrestrained by preconceived notions about the disease. In addition to highlighting biological pathways beyond the classical pathology hallmarks, these advances have revitalized drug discovery efforts and are driving improvements in clinical tools. We review genetic, epigenomic, and gene expression findings related to AD pathogenesis and explore how their integration enables a better understanding of the multicellular imbalances contributing to this heterogeneous condition. The frontiers opening on the back of these research milestones promise a future of AD care that is both more personalized and predictive.

引用

页数：18

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