Genomic and Epigenomic Biomarkers of Immune Checkpoint Immunotherapy Response in Melanoma: Current and Future Perspectives

被引:4
作者
Hossain, Sultana Mehbuba [1 ,2 ]
Carpenter, Carien [1 ]
Eccles, Michael R. [1 ,2 ]
机构
[1] Univ Otago, Dunedin Sch Med, Dept Pathol, Dunedin 9016, New Zealand
[2] Maurice Wilkins Ctr Mol Biodiscovery, Level 2,3A Symonds St, Auckland 1010, New Zealand
关键词
melanoma; immunotherapy; PD-L1; expression; mutation burden; neoantigens; DNA methylation; m6A RNA methylation; long non-coding RNAs; DNA MISMATCH REPAIR; TUMOR MUTATIONAL BURDEN; PD-1; BLOCKADE; MICROSATELLITE INSTABILITY; CANCER-IMMUNOTHERAPY; RNA METHYLATION; COLON-CANCER; EXPRESSION; MICROENVIRONMENT; MECHANISMS;
D O I
10.3390/ijms25137252
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Immune checkpoint inhibitors (ICIs) demonstrate durable responses, long-term survival benefits, and improved outcomes in cancer patients compared to chemotherapy. However, the majority of cancer patients do not respond to ICIs, and a high proportion of those patients who do respond to ICI therapy develop innate or acquired resistance to ICIs, limiting their clinical utility. The most studied predictive tissue biomarkers for ICI response are PD-L1 immunohistochemical expression, DNA mismatch repair deficiency, and tumour mutation burden, although these are weak predictors of ICI response. The identification of better predictive biomarkers remains an important goal to improve the identification of patients who would benefit from ICIs. Here, we review established and emerging biomarkers of ICI response, focusing on epigenomic and genomic alterations in cancer patients, which have the potential to help guide single-agent ICI immunotherapy or ICI immunotherapy in combination with other ICI immunotherapies or agents. We briefly review the current status of ICI response biomarkers, including investigational biomarkers, and we present insights into several emerging and promising epigenomic biomarker candidates, including current knowledge gaps in the context of ICI immunotherapy response in melanoma patients.
引用
收藏
页数:17
相关论文
共 121 条
[1]   Review of diagnostic, prognostic, and predictive biomarkers in melanoma [J].
Ankeny, Jacob S. ;
Labadie, Brian ;
Luke, Jason ;
Hsueh, Eddy ;
Messina, Jane ;
Zager, Jonathan S. .
CLINICAL & EXPERIMENTAL METASTASIS, 2018, 35 (5-6) :487-493
[2]   Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell-Cell Interactions That Predict Immunotherapy Response [J].
Antoranz, Asier ;
Van Herck, Yannick ;
Bolognesi, Maddalena M. ;
Lynch, Seodhna M. ;
Rahman, Arman ;
Gallagher, William M. ;
Boecxstaens, Veerle ;
Marine, Jean-Christophe ;
Cattoretti, Giorgio ;
van den Oord, Joost J. ;
De Smet, Frederik ;
Bechter, Oliver ;
Bosisio, Francesca M. .
CANCER RESEARCH, 2022, 82 (18) :3275-3290
[3]   A study of genomic instability in early preneoplastic colonic lesions [J].
Beggs, A. D. ;
Domingo, E. ;
Abulafi, M. ;
Hodgson, S. V. ;
Tomlinson, I. P. M. .
ONCOGENE, 2013, 32 (46) :5333-5337
[4]   Characterization of an adaptive immune response in microsatellite-instable colorectal cancer [J].
Boissiere-Michot, Florence ;
Lazennec, Gwendal ;
Frugier, Helene ;
Jarlier, Marta ;
Roca, Lise ;
Duffour, Jacqueline ;
Du Paty, Emilie ;
Laune, Daniel ;
Blanchard, France ;
Le Pessot, Florence ;
Sabourin, Jean-Christophe ;
Bibeau, Frederic .
ONCOIMMUNOLOGY, 2014, 3 (06)
[5]  
Boland CR, 2010, GASTROENTEROLOGY, V138, P2073, DOI [10.1053/j.gastro.2010.04.024, 10.1053/j.gastro.2009.12.064]
[6]   Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival [J].
Brown, Scott D. ;
Warren, Rene L. ;
Gibb, Ewan A. ;
Martin, Spencer D. ;
Spinelli, John J. ;
Nelson, Brad H. ;
Holt, Robert A. .
GENOME RESEARCH, 2014, 24 (05) :743-750
[7]   The Dark Side of Melanin Secretion in Cutaneous Melanoma Aggressiveness [J].
Cabaco, Luis C. ;
Tomas, Ana ;
Pojo, Marta ;
Barral, Duarte C. .
FRONTIERS IN ONCOLOGY, 2022, 12
[8]   Mechanisms Controlling PD-L1 Expression in Cancer [J].
Cha, Jong-Ho ;
Chan, Li-Chuan ;
Li, Chia-Wei ;
Hsu, Jennifer L. ;
Hung, Mien-Chie .
MOLECULAR CELL, 2019, 76 (03) :359-370
[9]   Marked Global DNA Hypomethylation Is Associated with Constitutive PD-L1 Expression in Melanoma [J].
Chatterjee, Aniruddha ;
Rodger, Euan J. ;
Ahn, Antonio ;
Stockwell, Peter A. ;
Parry, Matthew ;
Motwani, Jyoti ;
Gallagher, Stuart J. ;
Shklovskaya, Elena ;
Tiffen, Jessamy ;
Eccles, Michael R. ;
Hersey, Peter .
ISCIENCE, 2018, 4 :312-+
[10]   Oncology Meets Immunology: The Cancer-Immunity Cycle [J].
Chen, Daniel S. ;
Mellman, Ira .
IMMUNITY, 2013, 39 (01) :1-10