Enzyme-responsive design combined with photodynamic therapy for cancer treatment

被引：4
作者：
Zhi, Siying [1 ,2 ]
Huang, Meixin [1 ,2 ]
Cheng, Kui [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China
[2] Southern Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Res & Evaluat Drug Metab, Guangzhou 510515, Peoples R China
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 05期
基金：
中国国家自然科学基金;
关键词：
photodynamic therapy; photosensitizers; enzyme-responsive drugs; Matrix metalloproteinases; cathepsin B; hyaluronidase; nitroreductase; CATHEPSIN-B; MATRIX-METALLOPROTEINASE; TRIGGERED RELEASE; MOLECULAR BEACON; DELIVERY-SYSTEM; TUMOR INVASION; BREAST-CANCER; DRUG-RELEASE; PHOTOSENSITIZER; NANOPARTICLES;
D O I：
10.1016/j.drudis.2024.103965
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Photodynamic therapy (PDT) is a noninvasive cancer treatment that has garnered signi ficant attention in recent years. However, its application is still hampered by certain limitations, such as the hydrophobicity and low targeting of photosensitizers (PSs) and the hypoxia of the tumor microenvironment. Nevertheless, the fusion of enzymeresponsive drugs with PDT offers novel solutions to overcome these challenges. Utilizing the attributes of enzymeresponsive drugs, PDT can deliver PSs to the target site and selectively release them, thereby enhancing therapeutic outcomes. In this review, we spotlight recent advances in enzyme -responsive materials for cancer treatment and primarily delineate their application in combination with PDT.
引用
收藏
页码：1 / 19
页数：19
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