Triglyceride-Glucose Index as Predictor for Hypertension, CHD and STROKE Risk among Non-Diabetic Patients: A NHANES Cross-Sectional Study 2001-2020

被引：9

作者：

Sawaf, Bisher ^{[1
]}

Swed, Sarya ^{[2
]}

Alibrahim, Hidar ^{[2
]}

Bohsas, Haidara ^{[2
]}

Dave, Tirth ^{[3
]}

Nasif, Mohamad Nour ^{[2
]}

Hafez, Wael ^{[4
,5
]}

Tashrifwala, Fatema Ali Asgar ^{[6
]}

Jabban, Yazan Khair Eldien ^{[7
]}

Al-Rassas, Safwan ^{[8
]}

Saleh, Heba haj ^{[2
]}

Zaidi, Abdul Rehman Zia ^{[9
]}

Alghalyini, Baraa ^{[9
]}

Mohamed, Shaymaa Abdelmaboud ^{[10
,17
]}

Mohamed, Waleed Farouk ^{[11
]}

Farwati, Amr ^{[1
]}

Seijari, Mohammed Najdat ^{[1
]}

Battikh, Naim ^{[12
]}

Elnagar, Basma ^{[13
]}

Iqbal, Seema ^{[14
]}

Robles-Velasco, Karla ^{[15
,16
]}

Cherrez-Ojeda, Ivan ^{[15
,16
]}

机构：

[1] Hamad Med Corp, Dept Internal Med, Doha, Qatar

[2] Aleppo Univ, Fac Med, Aleppo, Syria

[3] Bukovinian State Med Univ, Chernovtsy, Ukraine

[4] NMC Royal Hosp, 16th St, Abu Dhabi, U Arab Emirates

[5] Natl Res Ctr, Med Res & Clin Studies Inst, Dept Internal Med, Cairo, Egypt

[6] Stamford Hlth, Dept Res & Discovery, Stamford, CT USA

[7] Damascus Univ, Fac Med, Damascus, Syria

[8] Thamar Univ, Fac Med, Dhamar, Yemen

[9] Alfaisal Univ, Coll Med, Dept Family & Community Med, Riyadh, Saudi Arabia

[10] Natl Heart Inst, Cardiol Dept, Ibn El Nafees Sq, Agouza, Egypt

[11] Healthpoint Hosp, Abu Dhabi, U Arab Emirates

[12] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA

[13] Tanta Univ, Fac Med, Cardiovasc Dept, Cardiovasc Med, Tanta, Egypt

[14] Univ Peshawar, Khyber Med Coll, Peshawar 25120, Pakistan

[15] Univ Espiritu Santo, Samborondon, Ecuador

[16] Respiralab Res Grp, Guayaquil, Ecuador

[17] Al Salam Specialist Hosp, Lab Dept, Bldg 1,Rd 39,Block 941, Riffa 80278, Bahrain

来源：

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH | 2024年 / 14卷 / 03期

关键词：

TyG index; Cardiovascular diseases; NHANES; CARDIOVASCULAR OUTCOMES; ASSOCIATION; POPULATION; DISEASE;

D O I：

10.1007/s44197-024-00269-7

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Cardiovascular disease (CVD) is a leading cause of global mortality. Early intervention and prevention of CVD depend on accurately predicting the risk of CVD. This study aimed to investigate the association between the TyG index and the risk of coronary heart disease (CHD), congestive heart failure (CHF), heart attack (HA), stroke, and hypertension (HTN) among patients without diabetes in the United States. Methods In this retrospective, cross-sectional study, we used data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2020. We conducted several regression analysis models and calculated the sensitivity and specificity of (TyG) index for predicting the onset of CHD, CHF, HA, stroke, and HTN. Results A total of 10,937 individuals without diabetes participated in our study. Individuals with a TyG index greater than 8.96 displayed significant increasing in various parameters, including BMI, systolic/diastolic blood pressure, total cholesterol, LDL, and Apo-B levels (p < 0.001). Almost all regression models ensured that a higher TyGI value was associated with higher odds of having CHD, CHF, HA, stroke, and HTN, which patients with a TyGI value higher than 8.96 have odds ratios of 2.24-5.58 for CHD, 1.68-4.42 for stroke, 2.45-3.77 for HA and 1.75-3.93 for HTN comparing than patients with a TyGI value lower than 8.11 (p-value < 0.05).We evaluated the predictive value of the TyG index for each endpoint, obtaining the following area under the curve (AUC) values: 54.75% for CHF (95% CI: 0.542-0.614), 52.32% for stroke (95% CI: 0.529-0.584), 55.67% for HA (95% CI: 0.595-0.646), 55.59% for HTN (95% CI: 0.574-0.597), and 50.31% for CHD (95% CI: 0.592-0.646). Conclusion The TyG index showed a strong correlation with cardiovascular risk factors in individuals without diabetes, however it was a poor predictor of almost studied cardiovascular diseases.

引用

页码：1152 / 1166

页数：15

共 35 条

[31] Combined association of triglyceride-glucose index and systolic blood pressure with all-cause and cardiovascular mortality among the general population [J].